protein

RAB10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

2Hypotheses

2Analyses

50Outgoing

49Incoming

0Experiments

2Debates

Summary

RAB10 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 38 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	RAB10
Full Name	RAB10, Member RAS Oncogene Family
Chromosome	2
Protein Family	Rab GTPase family
Function	RAB10 encodes a member of the Rab GTPase family involved in intracellular membrane trafficking
Subcellular Localization	RAB10 localizes to:
Molecular Weight	23 kDa
Exons	Multiple protein-coding exons spanning approximately 15 kb
Pathways	Autophagy, Mitophagy, autophagy pathway, mitophagy
UniProt ID	Q9Y2P8
NCBI Gene ID	10890
Ensembl ID	ENSG00000100705
GeneCards	RAB10
Human Protein Atlas	RAB10
Location	2p22.3
Associated Diseases	Als, Parkinson
Interactions	Actin, AND, APOE, APOE3, ATP8B1, AUTOPHAGY
KG Connections	115 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB10 — AlphaFold Q9Y2P8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

rab10 Gene

gene · 973 words

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Pathway Diagram

graph TD
    RAB10["RAB10"]
    Als{"Als"}
    RAB10 -->|"associated with"| Als
    Parkinson{"Parkinson"}
    RAB10 -->|"activates"| Parkinson
    RAB10 -->|"regulates"| Als
    ALS{"ALS"}
    RAB10 -->|"associated with"| ALS
    RAB3A["RAB3A"]
    RAB10 -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB10 -->|"associated with"| Exocytosis
    PARK16["PARK16"]
    RAB10 -->|"activates"| PARK16
    RAB11B["RAB11B"]
    RAB10 -->|"associated with"| RAB11B
    RAB3C["RAB3C"]
    RAB10 -->|"associated with"| RAB3C
    RAB5A["RAB5A"]
    RAB10 -->|"associated with"| RAB5A
    RAB5["RAB5"]
    RAB10 -->|"associated with"| RAB5
    RAB27B["RAB27B"]
    RAB10 -->|"associated with"| RAB27B
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB10
    RAB27B -->|"associated with"| RAB10
    RAB3C -->|"associated with"| RAB10
    RAB5 -->|"associated with"| RAB10
    RAB3B["RAB3B"]
    RAB3B -->|"associated with"| RAB10
    RAB5A -->|"associated with"| RAB10
    RAB11B -->|"associated with"| RAB10
    RAB29["RAB29"]
    RAB29 -->|"inhibits"| RAB10
    LRRK2["LRRK2"]
    LRRK2 -->|"inhibits"| RAB10
    RAB3A -->|"associated with"| RAB10
    PARK16 -->|"activates"| RAB10
    AND["AND"]
    AND -->|"associated with"| RAB10
    style RAB10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
Autophagy	regulates	process	0.85
OPTN	interacts_with	protein	0.82
MITOPHAGY	promotes	process	0.80
synaptic vesicle trafficking	regulates	process	0.75
Alzheimer	therapeutic_target	disease	0.65
Parkinson	phosphorylates	disease	0.65
Als	transports	disease	0.65
ALS	phosphorylates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	regulates	disease	0.65
ALS	associated_with	disease	0.65
RAB29	inhibits	gene	0.60
AND	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PARKINSON	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Parkinson	associated_with	disease	0.60
AND	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB4B	associated_with	gene	0.60
Autophagy	activates	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
Mitophagy	activates	pathway	0.60
AND	causes	gene	0.60
VPS35	expressed_in	gene	0.60
Actin	activates	protein	0.60
Fus	associated_with	protein	0.60
App	associated_with	protein	0.60
autophagy pathway	participates_in	pathway	0.60
RAB12	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
RAB3A	associated_with	gene	0.60
PARK16	activates	gene	0.60
RAB7A	activates	gene	0.60
PAK1	activates	gene	0.60
CDC42	activates	gene	0.60
Synaptic Vesicle	associated_with	pathway	0.60
OPTINEURIN	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
PINK1	associated_with	gene	0.60
PTEN	activates	gene	0.60
OPTN	activates	gene	0.60
Rb	activates	protein	0.60
GENES	activates	gene	0.60
RAB29	phosphorylates	entity	0.60

Incoming (49)

Source	Relation	Type	Str
PINK1	interacts_with	gene	0.80
MITOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
GENES	activates	gene	0.60
RAB4B	associated_with	gene	0.60
RAB27B	associated_with	gene	0.60
RAB3C	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB5A	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB29	inhibits	gene	0.60
PTEN	activates	gene	0.60
LRRK2	inhibits	gene	0.60
APOE3	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
PARK16	activates	gene	0.60
LRRK2	regulates	gene	0.60
PINK1	associated_with	gene	0.60
LRRK2	targets	gene	0.60
PINK1	targets	gene	0.60
PRKN	targets	gene	0.60
APOE	interacts_with	gene	0.60
ATP8B1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
PLCG2	interacts_with	gene	0.60
JIP4	interacts_with	gene	0.60
JIP4	activates	gene	0.60
LRRK2	activates	gene	0.60
CAV1	regulates	gene	0.60
OPTN	activates	gene	0.60
PRKN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
PARKIN	activates	gene	0.60
PAK1	activates	gene	0.60
LRRK2	phosphorylates	entity	0.60
SNCA	expressed_in	gene	0.60
LRRK2	interacts_with	gene	0.60
OPTINEURIN	activates	gene	0.60
PARKINSON	activates	gene	0.60
RAB3A	associated_with	gene	0.60
PRKN	co_expressed_with	gene	0.50
PTEN	co_expressed_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes	0.680	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
Rab12 may better report chronic lysosomal stress biology tha	0.670	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo