Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AGEs: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| RAGE | binds_to | protein | 0.90 |
| Protein Misfolding | promotes | process | 0.85 |
| OPTN | inhibits | gene | 0.85 |
| neurodegenerative diseases | implicated_in | disease | 0.80 |
| mitochondrial dysfunction | causes | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MGO | generates | metabolite | 0.92 |
| Insulin Resistance | promotes | phenotype | 0.90 |
| insulin resistance | contributes_to | phenotype | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405] | Li S, Yan Z, Zhi X, Zheng W, Zhang Z et | Bioact Mater | 2026 | 0 |
| Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939] | Wan D, Qi Y, Kang Y, Liang F, Wang Q et | RSC Med Chem | 2026 | 0 |
| Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906] | Gao Z, Wang Y, Ren Y, Lyu J | J Neurochem | 2026 | 0 |
| VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560] | Lee S, Park S, Bang H, Kim SU, Park YH e | Genes (Basel) | 2026 | 0 |
| N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663] | Song P, Chen C, Franchini R, Duong B, Wa | J Clin Invest | 2026 | 0 |
| The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708] | Buneeva OA, Medvedev AE | Biomed Khim | 2026 | 0 |
| Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978] | Deng IB, Bu M, Follett J, Sharp R, Mamai | bioRxiv | 2026 | 0 |
| Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440] | Santinelli L, Pratuseviciute N, Lange LM | Mov Disord | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AGEs in their description or question text
Score: 0.520 · neurodegeneration · 2026-04-21
## Mechanistic Overview M-Sec/TNTA2-mediated tunneling nanotube formation drives glia-neuron tau propagation in mid-stag
Score: 0.516 · Alzheimer's disease · 2026-04-23
## Mechanistic Overview Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axi
Score: 0.496 · neurodegeneration · 2026-04-22
## Mechanistic Overview TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Through CSF1R-Mediated