gene

GEPHYRIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEPHYRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

39Outgoing

12Incoming

0Experiments

0Debates

Summary

Gephyrin is a crucial scaffolding protein that clusters GABA-A and glycine receptors at inhibitory synapses, essential for inhibitory synaptic transmission and also involved in molybdenum cofactor synthesis. Associated with epilepsy, Alzheimer's disease, and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	GEPHYRIN
Chromosome	14q23.3
Function	is a multifunctional scaffolding protein that plays critical roles in the central nervous system.
Molecular Weight	83 kDa
Amino Acids	736 aa
Exons	22
Pathways	Complement, Endocytosis, Exocytosis, Long-Term Potentiation
UniProt ID	Q9NQX3
NCBI Gene ID	10254
Ensembl ID	ENSG00000171680
OMIM	603930
GeneCards	GEPHYRIN
Human Protein Atlas	GEPHYRIN
Associated Diseases	neurodegeneration
Interactions	AKT, BRAIN INFLAMMATION, Chemokine, CX3CR1, CYTOKINES, EPILEPSY
KG Connections	51 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GEPHYRIN — AlphaFold Q9NQX3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GEPHYRIN

gene · 1694 words

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Pathway Diagram

graph TD
    GEPHYRIN["GEPHYRIN"]
    Ms{"Ms"}
    GEPHYRIN -->|"inhibits"| Ms
    Depression{"Depression"}
    GEPHYRIN -->|"inhibits"| Depression
    PI3K["PI3K"]
    GEPHYRIN -->|"inhibits"| PI3K
    CYTOKINES["CYTOKINES"]
    GEPHYRIN -->|"inhibits"| CYTOKINES
    AKT["AKT"]
    GEPHYRIN -->|"inhibits"| AKT
    Synaptic_Plasticity(["Synaptic Plasticity"])
    GEPHYRIN -->|"inhibits"| Synaptic_Plasticity
    Akt(["Akt"])
    GEPHYRIN -->|"inhibits"| Akt
    Pi3K(["Pi3K"])
    GEPHYRIN -->|"inhibits"| Pi3K
    neurodegeneration["neurodegeneration"]
    GEPHYRIN -->|"implicated in"| neurodegeneration
    style GEPHYRIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Epilepsy	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Als	regulates	disease	0.65
Depression	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
ALS	inhibits	disease	0.65
DEPRESSION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
Endocytosis	regulates	pathway	0.60
Exocytosis	regulates	pathway	0.60
Complement	regulates	pathway	0.60
Long-Term Potentiation	regulates	pathway	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
C1Q	regulates	gene	0.60
ARC	regulates	gene	0.60
CD47	regulates	gene	0.60
EPILEPSY	inhibits	gene	0.60
Neurogenesis	inhibits	pathway	0.60
CYTOKINES	inhibits	gene	0.60
Microglia	inhibits	cell_type	0.60
Synaptic Plasticity	inhibits	pathway	0.60
Akt	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
CX3CR1	inhibits	gene	0.60
Synaptic Vesicle	inhibits	pathway	0.60
NLGN1	interacts_with	gene	0.60
SYNAPSIN2	inhibits	gene	0.60
Interleukin	inhibits	protein	0.60
Chemokine	inhibits	protein	0.60
Cortex	expressed_in	brain_region	0.55
Microglia	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Cortex	inhibits	brain_region	0.50
Proteins	inhibits	protein	0.50
NLGN2	interacts_with	gene	0.50

Incoming (12)

Source	Relation	Type	Str
genes-gephyrin	documents	wiki	1.00
genes-gephyrin	describes	wiki	1.00
PKC	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
SNAP25	regulates	gene	0.60
NLGN2	interacts_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
EPILEPSY	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BRAIN INFLAMMATION	inhibits	gene	0.60
SYNAPSIN2	inhibits	gene	0.60
SYNAPSE	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GEPHYRIN in their description or question text

No additional research found