concept

NFKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

873Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NFKB is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with ALS, Als, Alzheimer. Connected to 305 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NFKB
Key Genes/Proteins	ABIN1, ABLIM1, ACHE, ACTB, AD, AGER
Related Diseases	ACCELERATED_AGING, Als, ALS, Alzheimer, Alzheimer Disease

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NFKB["NFKB"]
    NFKB -->|"regulates"| C3["C3"]
    NFKB -->|"regulates"| IL8["IL8"]
    NFKB -->|"regulates"| GFAP["GFAP"]
    NFKB -->|"regulates"| BACE1["BACE1"]
    NFKB -->|"inhibits"| Als["Als"]
    NFKB -->|"activates"| Cancer["Cancer"]
    BRSK2["BRSK2"] -->|"activates"| NFKB
    STING1["STING1"] -->|"regulates"| NFKB
    ROS["ROS"] -->|"activates"| NFKB
    mitochondrial_ROS["mitochondrial ROS"] -->|"activates"| NFKB
    PINK1["PINK1"] -->|"regulates"| NFKB
    IL_6["IL-6"] -->|"activates"| NFKB
    IL17["IL17"] -->|"activates"| NFKB
    STING["STING"] -->|"activates"| NFKB

Outgoing (446)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.95
Immune Development	regulates	process	0.95
SASP	activates	process	0.95
Immune Response	regulates	process	0.95
NEUROINFLAMMATION	activates	entity	0.95
SASP	regulates	entity	0.95
Neuroinflammation	activates	process	0.95
C3	regulates	protein	0.94
NF-kB signaling	participates_in	pathway	0.90
Neuroinflammation	mediates	process	0.90
NEUROINFLAMMATION	mediates	entity	0.90
IL8	upregulates	protein	0.90
SQSTM1	upregulates	gene	0.90
Alzheimer's Disease	contributes_to	disease	0.90
NLRP3	upregulates	protein	0.90
IL-6	regulates	protein	0.88
Immune Aging	involved_in	process	0.85
Inflammatory Cytokine Secretion	activates	process	0.85
Neuroinflammation	involved_in	process	0.85
BNIP3	regulates	gene	0.85
NLRP3	activates	protein	0.85
Inflammation	mediates	process	0.85
Microglial Dysfunction	mediates	process	0.82
DNMT1	associated_with	gene	0.80
Alzheimer's disease	implicated_in	disease	0.80
TG2	activates	gene	0.80
Intestinal Inflammation	mediates	process	0.80
TLR	interacts_with	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
IL6	upregulates	gene	0.80
Oxidative Stress	involved_in	process	0.80
Alzheimer's disease	dysregulated_in	disease	0.80
NFKBIA	triggers_ubiquitination_dependent_degradation_by_TRIM25	protein	0.80
IFN	interacts_with	pathway	0.80
MTOR	associated_with	gene	0.80
Mtor	associated_with	pathway	0.80
ASTROCYTES	inhibits	gene	0.80
MICROGLIA	inhibits	gene	0.80
UBIQUITIN	activates	gene	0.80
Dementia	inhibits	disease	0.75
Als	inhibits	disease	0.75
Capillary Dysfunction	associated_with	phenotype	0.75
MICROGLIA	interacts_with	cell_type	0.75
ASTROCYTES	interacts_with	cell_type	0.75
Alzheimer	associated_with	disease	0.75
GFAP	regulates	protein	0.72
IL8	regulates	protein	0.72
NRF2	targets	gene	0.70
TAU	activates	gene	0.70
PYCARD	activates	gene	0.70

Incoming (427)

Source	Relation	Type	Str
RANK	activates	protein	0.95
IKB	interacts_with	protein	0.95
ABLIM1	activates	protein	0.95
IKK	interacts_with	protein	0.95
TGM2	activates	entity	0.95
NFKBIA	inhibits	protein	0.90
IRISIN	inhibits	protein	0.90
BRSK2	activates	protein	0.90
Polyphenols	associated_with	compound	0.90
IKBA	interacts_with	protein	0.90
IKBA	inhibits	protein	0.90
IκB	inhibits	protein	0.90
Vitamin B3	inhibits	drug	0.88
Vitamin B1	inhibits	drug	0.88
Vitamin B2	inhibits	drug	0.88
RIPK3	activates	protein	0.87
AKT	activates	protein	0.85
PPARG	modulates	gene	0.85
FNDC5	inhibits	protein	0.85
STREM2	activates	protein	0.85
Copper	activates	compound	0.85
RLN	phosphorylates	protein	0.85
Dopamine	inhibits	compound	0.85
NFE2L2	modulates	gene	0.85
Astrocytes	activates	cell_type	0.85
Microglia	activates	cell_type	0.85
Glutamate	activates	compound	0.80
STING1	regulates	gene	0.80
TAU PROTEIN	interacts_with	protein	0.80
AMPK	interacts_with	protein	0.80
CCN2	regulates	gene	0.80
IL1	interacts_with	pathway	0.80
P75NTR	activates	protein	0.80
METHIONINE RESTRICTION	inhibits	biological_process	0.80
APOE	interacts_with	gene	0.75
Flavonoids	modulates	compound	0.75
CCL2	activates	gene	0.70
NEURONS	inhibits	cell_type	0.70
GSK3B	inhibits	gene	0.70
HSP90	expresses	gene	0.70
AMPK	activates	gene	0.70
CREB	activates	gene	0.70
LAMP1	targets	gene	0.70
APP	mediates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
GASDERMIN	activates	gene	0.70
DBH	activates	gene	0.70
MAPT	activates	gene	0.70
LRP1	activates	gene	0.70
GSK3B	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning NFKB in their description or question text

No additional research found

NFKB

Understanding Entity Pages

Summary

Wiki Pages (8)

nfkb-neurodegeneration

NFKBIA Gene (NFKB Inhibitor Alpha)

NFKB2 Gene

NFKBIA Protein

NFKB2 Protein

NFKBIE Gene

NFKB1 Gene

NFKBIB Gene