gene 607 words KG: NFKB1
Contents

NFKB1 Gene

🧬 Gene Info
Gene SymbolNFKB1
Full NameNuclear Factor Kappa B Subunit 1
Chromosome4q24
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionNFKB1 encodes p105, which is processed to p50, a DNA-binding subunit of NF-κB.
Molecular Weight105 kDa (p105), 50 kDa (p50)
Amino Acids968 aa
PathwaysNfkb, NFKB, NF-κB, NF-κB pathway
UniProt IDP19838
NCBI Gene ID4790
Ensembl IDENSG00000109320
OMIM164011
GeneCardsNFKB1
Human Protein AtlasNFKB1
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/CompoundsBerberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
InteractionsALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND
SciDEX HypothesesDual NF-κB/MMP Inhibition Strategy
KG Connections411 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (12)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75

Related Analyses (11)

Blood-brain barrier tight junction disruption by neuroinflam
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (2)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: activates

Knowledge Graph (12 edges)

hyperoxia activates NFKB1
TNF activates NFKB1
TRAF6 activates NFKB1
NFKB1 regulates TNF
NFKB1 regulates IL1B
NFKB1 therapeutic_target TRIM24
NFKB1 therapeutic_target TDP1
NFKB1 therapeutic_target MAPK1
NFKB1 therapeutic_target CTSD
NFKB1 therapeutic_target HIF1A

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