pathway

NF-kB signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-kB signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

435Connections

0Hypotheses

0Analyses

41Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🔀 Pathway Info

Name	NF-kB signaling
Key Genes/Proteins	ABCA1, ABCG1, ACE, ACSL4, ACTB, ACVR1
Related Diseases	aging

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NF-κB Signaling Pathway in Neurodegeneration

mechanism · 1466 words

→

Pathway Diagram

graph TD
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NEMO["NEMO"] -->|"activates"| NF_kB_signaling["NF-kB signaling"]
    style NEMO fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| NF_kB_signaling["NF-kB signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TLR4["TLR4"] -->|"participates in"| NF_kB_signaling["NF-kB signaling"]
    style TLR4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| NF_kB_signaling["NF-kB signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| NF_kB_signaling["NF-kB signaling"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style NF_kB_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (41)

Target	Relation	Type	Str
unfolded protein response	crosstalk_with	pathway	0.90
neurons	active_in	cell_type	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
endothelial cells	active_in	cell_type	0.90
astrocytes	active_in	cell_type	0.90
pyroptosis	crosstalk_with	pathway	0.90
TGF-beta signaling	crosstalk_with	pathway	0.90
microglia	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
B cells	active_in	cell_type	0.90
blood-brain barrier	active_in	brain_region	0.80
lipid metabolism	crosstalk_with	pathway	0.70
spinal cord	active_in	brain_region	0.70
oxidative stress response	crosstalk_with	pathway	0.70
pyroptosis	mediates	process	0.70
oligodendrocytes	active_in	cell_type	0.70
hippocampus	active_in	brain_region	0.70
monocytes	active_in	cell_type	0.70
CHOLESTEROL	activates	phenotype	0.65
CHOLESTEROL	regulates	phenotype	0.65
HMGCR	regulates	gene	0.65
HMGCR	activates	gene	0.65
cortex	active_in	brain_region	0.60
T cells	active_in	cell_type	0.60
necroptosis	crosstalk_with	pathway	0.60
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60
dopaminergic neurons	active_in	cell_type	0.60
protein misfolding	mediates	process	0.60
ER stress	mediates	process	0.60
pyramidal neurons	active_in	cell_type	0.60
substantia nigra	active_in	brain_region	0.60
ubiquitin-proteasome	crosstalk_with	pathway	0.60
cGAS-STING	crosstalk_with	pathway	0.60
striatum	active_in	brain_region	0.60
MICROGLIA	associated_with	cell_type	0.50
AMYLOID	associated_with	protein	0.50
AMYLOID-BETA	associated_with	protein	0.50
HMGCR	associated_with	gene	0.45
CHOLESTEROL	associated_with	phenotype	0.45

Incoming (394)

Source	Relation	Type	Str
ATP	participates_in	gene	0.90
AMPK	participates_in	gene	0.90
TNF	participates_in	gene	0.90
C3	participates_in	gene	0.90
SIRT1	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
NFKB	participates_in	gene	0.90
AKT	participates_in	gene	0.90
ERK	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
NEMO	activates	protein	0.90
JAK	participates_in	gene	0.90
JAK-STAT signaling	crosstalk_with	pathway	0.90
MAPK signaling	crosstalk_with	pathway	0.90
Alzheimer's disease	involves	disease	0.90
PI3K	participates_in	gene	0.90
TLR4	participates_in	gene	0.90
ALOX5	regulates	gene	0.85
microglia	active_in	cell_type	0.85
IL-6	participates_in	gene	0.85
IL1B	participates_in	gene	0.80
TNF receptor	activates	receptor	0.80
NFKBIA	participates_in	gene	0.80
diabetes	involves	disease	0.80
traumatic brain injury	involves	disease	0.80
ROS	participates_in	gene	0.80
NFKB1	participates_in	gene	0.80
IFN	participates_in	gene	0.80
STAT3	participates_in	gene	0.80
stroke	involves	disease	0.80
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles	inhibits	cell_type	0.80
GFAP	participates_in	gene	0.80
RNA	participates_in	gene	0.80
BMAL1	participates_in	gene	0.75
TGF	participates_in	gene	0.75
IL-10	participates_in	gene	0.75
neurons	active_in	cell_type	0.75
berberine	modulates	compound	0.70
curcumin	modulates	compound	0.70
HMGB1	participates_in	gene	0.70
GBM	participates_in	gene	0.70
aging	involves	disease	0.70
quercetin	modulates	compound	0.70
TBK1	participates_in	gene	0.70
STAT1	participates_in	gene	0.70
ITGB1	participates_in	gene	0.70
MMP2	participates_in	gene	0.70
TLR	participates_in	gene	0.70
TNFR1	participates_in	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NF-kB signaling in their description or question text

No additional research found