| Gene Symbol | MAP3K6 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 6 |
| Aliases | MEKK6 |
| Chromosome | 1p36.21 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that functions as an upstream activator of the p38 MAPK signaling pathway[@matsumoto2005]. |
| Amino Acids | 372 aa |
| Pathways | MAPK signaling, MAPK, MAPK pathway, pathway: **Direct Phosphorylation Targets**: |
| UniProt ID | [O43283](https://www.uniprot.org/uniprot/O43283) |
| Ensembl ID | ENSG00000142733 |
| GeneCards | MAP3K6 |
| Human Protein Atlas | MAP3K6 |
| ATP-binding pocket | Located in the deep cleft between N-lobe and C-lobe |
| Activation loop | ContainsThr-293 and Ser-297, sites of autophosphorylation |
| DFG motif | Asp-Phe-Gly (residues 287-289), essential for catalytic activity |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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