Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ITGB6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ITGB6 |
| Key Genes/Proteins | AND, CANCER, HER3, KRAS, Mek, MEK |
| Related Diseases | Als, ALS, Cancer, Non-Small Cell Lung Cancer |
graph TD
ITGB6["ITGB6"]
ITGB6 -->|"target for"| Als["Als"]
ITGB6 -->|"target for"| Cancer["Cancer"]
ITGB6 -->|"interacts"| ALS["ALS"]
ITGB6 -->|"target for"| KRAS["KRAS"]
ITGB6 -->|"causes"| HER3["HER3"]
ITGB6 -->|"causes"| AND["AND"]
ITGB6 -->|"causes"| MEK["MEK"]
HER3 -->|"target for"| ITGB6
PRMT5["PRMT5"] -->|"target for"| ITGB6
MEK -->|"causes"| ITGB6
CANCER["CANCER"] -->|"interacts"| ITGB6
KRAS -->|"target for"| ITGB6| Target | Relation | Type | Str |
|---|---|---|---|
| Tacrolimus-Induced Chronic Nephrotoxicity | implicated_in | disease | 0.90 |
| Tubular Injury | associated_with | phenotype | 0.85 |
| Renal Fibrogenesis | associated_with | process | 0.85 |
| Non-Small Cell Lung Cancer | associated_with | disease | 0.80 |
| STAT3 | therapeutic_target | gene | 0.80 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| CANCER | interacts_with | gene | 0.60 |
| KRAS | causes | gene | 0.60 |
| HER3 | therapeutic_target | gene | 0.60 |
| PRMT5 | therapeutic_target | gene | 0.60 |
| Raf | therapeutic_target | protein | 0.60 |
| Mek | therapeutic_target | protein | 0.60 |
| Ras | therapeutic_target | protein | 0.60 |
| KRAS | therapeutic_target | gene | 0.60 |
| AND | causes | gene | 0.60 |
| HER3 | causes | gene | 0.60 |
| MEK | causes | gene | 0.60 |
| PRMT5 | causes | gene | 0.60 |
| RAF | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ITGB6 in their description or question text
No additional research found