| Gene Symbol | MEKK2 |
| Full Name | MEKK2 (MEK Kinase 2) |
| Aliases | MEK Kinase 2 |
| Protein Family | MAP3K (MAP Kinase Kinase Kinase) family |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that functions as a mitogen-activated protein kinase kinase kinase (MAP3K) in the MAPK signaling cascades. |
| Primary Expression | Ubiquitous; high in brain, heart, skeletal muscle |
| Molecular Weight | 71.7 kDa |
| Amino Acids | 619 aa |
| Pathways | MAPK signaling, MAPK pathway, MAPK |
| UniProt ID | Q9Y252 |
| GeneCards | MEKK2 |
| Human Protein Atlas | MEKK2 |
| Activation Loop | ContainsThr-249 and Ser-252, which are phosphorylated for activation |
| ATP-Binding Site | Binds ATP and ATP-competitive inhibitors |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | MAPK |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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