| Gene Symbol | MEKK3 |
| Aliases | MAP3K3 |
| Protein Family | MAP3K serine/threonine kinases |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a critical upstream regulator of both NF-κB and MAPK signaling pathways. |
| Subcellular Localization | The kinase domain adopts the typical bilobal structure seen in protein kinases, with ATP binding in the deep cleft betwe |
| Molecular Weight | 75.1 kDa |
| Pathways | NF-κB, MAPK signaling |
| UniProt ID | Q99731 |
| GeneCards | MEKK3 |
| Human Protein Atlas | MEKK3 |
| Kinase domain ( residues 1-300) | The catalytic domain with serine/threonine kinase activity |
| REG1 regulatory domain (300-400) | Autoinhibitory region that maintains basal state |
| Proline-rich regions (400-500) | Sites for SH3 domain-containing protein interactions |
| C-terminal domain (500-650) | Regulatory region controlling subcellular localization |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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