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protein 559 words KG: HMGCRPROTEIN
Contents

HMGCR Protein — HMG-CoA Reductase

🔬 Protein Info
Gene SymbolHMGCR
Full Name3-Hydroxy-3-Methylglutaryl-CoA Reductase
AliasesHMGCRPROTEIN
Chromosome5
FunctionHMGCR plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
PathwaysAmyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Lipid Metabolism
UniProt ID[P04035](https://www.uniprot.org/uniprotkb/P04035/entry)
Ensembl IDENSG00000013113
GeneCardsHMGCR
Human Protein AtlasHMGCR
Associated DiseasesAD, Als, Alzheimer, Alzheimer disease, Alzheimer's disease
Known Drugs/Compounds25-Hydroxycholesterol, SIMVASTATIN, statins
InteractionsA2M, ABCA1, ACSL4, AGING, Akt, AKT
SciDEX HypothesesMembrane Lipid Composition Therapeutic Modulation
KG Connections812 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (16)

Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72CYP46A1 Overexpression Gene Therapy
Score: 0.73Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inALA-enriched Nutrition for APOE4 Carriers with MCI (NCT
clinical · Pages share 5 hypothesesLX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 5 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 5 hypothesesCORT108297 Phase 2 (NCT04601038) - Stress Attenuation i
clinical · Pages share 4 hypotheses

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