concept

HIF-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

2Hypotheses

1Analyses

45Outgoing

50Incoming

1Experiments

1Debates

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💡 Concept Info

Name	HIF-1
Key Genes/Proteins	VEGF

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HIF_1["HIF-1"]
    style HIF_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HIF_1 -->|"activates"| Als["Als"]
    HIF_1 -->|"activates"| Cancer["Cancer"]
    HIF_1 -->|"activates"| Ferroptosis["Ferroptosis"]
    HIF_1 -.->|"inhibits"| Ischemia["Ischemia"]
    HIF_1 -.->|"inhibits"| Fibrosis["Fibrosis"]
    HIF_1 -->|"activates"| Aging["Aging"]
    HIF_1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    TKT([TKT]) -->|"activates"| HIF_1
    IDH2([IDH2]) -->|"activates"| HIF_1
    TIGAR([TIGAR]) -->|"activates"| HIF_1
    FOXO([FOXO]) -->|"activates"| HIF_1
    HK2([HK2]) -->|"activates"| HIF_1
    MYC([MYC]) -->|"activates"| HIF_1
    PKM2([PKM2]) -->|"activates"| HIF_1
    GLUT1([GLUT1]) -->|"activates"| HIF_1
    GSK3([GSK3]) -->|"activates"| HIF_1
    MTORC1([MTORC1]) -->|"activates"| HIF_1

Outgoing (45)

Target	Relation	Type	Str
VEGF	upregulates	protein	0.85
Neuroinflammation	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Als	regulates	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Glioblastoma	activates	disease	0.60
Als	transports	disease	0.60
Ferroptosis	activates	disease	0.60
Ferroptosis	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Cancer	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Aging	activates	disease	0.60
Cancer	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Cancer	activates	disease	0.60
Als	activates	disease	0.60
Stroke	regulates	disease	0.60
Apoptosis	inhibits	pathway	0.55
Pi3K/Akt	inhibits	pathway	0.55
Glycolysis	activates	pathway	0.55
Apoptosis	contributes_to	pathway	0.55
Pi3K/Akt	activates	pathway	0.55
Mtor	activates	pathway	0.55
Autophagy	activates	pathway	0.55
Mapk	associated_with	pathway	0.55
Autophagy	regulates	pathway	0.55
Oxidative Stress	inhibits	pathway	0.55
Mtor	regulates	pathway	0.55
Epigenetic	regulates	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Blood-Brain Barrier	regulates	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Wnt	inhibits	pathway	0.55
Cholesterol	regulates	pathway	0.55
Immune Response	regulates	pathway	0.55
Lipid Metabolism	regulates	pathway	0.55
Glycolysis	regulates	pathway	0.55
Nf-Κb	therapeutic_target	pathway	0.55

Incoming (102)

Source	Relation	Type	Str
MTORC1	activates	gene	0.60
AMPK	activates	gene	0.60
FOXO	activates	gene	0.60
PKM2	activates	gene	0.60
GLUT1	activates	gene	0.60
GSK3	activates	gene	0.60
EIF4B	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
PABP1	activates	gene	0.60
CHAC2	activates	gene	0.60
HIF	activates	gene	0.60
HIF1	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
BCL-2	expressed_in	gene	0.60
CX43	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
STROKE	regulates	gene	0.60
G3BP1	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
OCLN	activates	gene	0.60
HMOX1	activates	gene	0.60
CD4	activates	gene	0.60
ABCA7	regulates	gene	0.60
LPL	regulates	gene	0.60
APOE4	regulates	gene	0.60
SYK	regulates	gene	0.60
TREM2	associated_with	gene	0.60
PPARG	regulates	gene	0.60
APOE	associated_with	gene	0.60
CNTN1	therapeutic_target	gene	0.60
NGF	therapeutic_target	gene	0.60
BDNF	activates	gene	0.60
HCRTR1	activates	gene	0.60
WIF1	inhibits	gene	0.60
LDHB	activates	gene	0.60
DJ-1	regulates	gene	0.60
RNA	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
SLC16A1	activates	gene	0.60
GBM	activates	gene	0.60
ANGPT1	associated_with	gene	0.60
PIK3R1	associated_with	gene	0.60
UCHL1	activates	gene	0.60
VEGFA	activates	gene	0.60
ANGPT1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
SNCA	regulates	gene	0.60
PARK7	regulates	gene	0.60
CASPASE3	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.793	neurodegeneration	What molecular mechanism causes VCP muta
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.793

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	Human atherosclerotic plaque s	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

closed · Rounds: 4 · Score: 0.78 · 2026-04-13

Related Research

Hypotheses and analyses mentioning HIF-1 in their description or question text

No additional research found