gene

HCRTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

333Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HCRTR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiovascular. Connected to 56 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	HCRT1
Full Name	HCRTR1
Protein Type	Gpcr
Target Class	Gpcr
Function	Small molecule antagonist blocking orexin receptor signaling
Mechanism of Action	Small molecule antagonist blocking orexin receptor signaling
Druggability	Medium (0.60)
Clinical Stage	Approved
Amino Acids	33 aa
Pathways	Circadian rhythm / glymphatic clearance, NF-κB signaling, Sleep-Wake Transition
UniProt ID	A6NMV7
GeneCards	HCRT1
Human Protein Atlas	HCRT1
Orexin-A (Hypocretin-1)	A 33-amino acid peptide with two disulfide bonds[@sakurai2007]
Orexin-B (Hypocretin-2)	A 28-amino acid linear peptide[@sakurai2007]
Associated Diseases	Addiction, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Propofol
Interactions	5-HT1AR, ACE, ADRA1A, ADRA1B, AND, AQP4
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	330 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HCRTR1 — AlphaFold A6NMV7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HCRTR1

gene · 765 words

→

Pathway Diagram

graph TD
    HCRTR1["HCRTR1"]
    Sleep_Wake_Transition(["Sleep-Wake Transition"])
    HCRTR1 -->|"associated with"| Sleep_Wake_Transition
    Hemodynamic_Stability["Hemodynamic Stability"]
    HCRTR1 -->|"associated with"| Hemodynamic_Stability
    Propofol["Propofol"]
    HCRTR1 -->|"interacts with"| Propofol
    neurodegeneration{"neurodegeneration"}
    HCRTR1 -->|"associated with"| neurodegeneration
    HCRTR2["HCRTR2"]
    HCRTR1 -->|"interacts with"| HCRTR2
    Als{"Als"}
    HCRTR1 -->|"associated with"| Als
    Obesity{"Obesity"}
    HCRTR1 -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    HCRTR1 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    HCRTR1 -->|"associated with"| Diabetes
    Cardiovascular{"Cardiovascular"}
    HCRTR1 -->|"associated with"| Cardiovascular
    HCRTR1 -->|"activates"| Ms
    HCRTR1 -->|"activates"| Als
    h_9e9fee95["h-9e9fee95"]
    h_9e9fee95 -->|"therapeutic target"| HCRTR1
    h_9e9fee95 -->|"targets"| HCRTR1
    HCRTR2 -->|"interacts with"| HCRTR1
    HCRTR2 -->|"regulates"| HCRTR1
    HCRTR2 -->|"therapeutic target"| HCRTR1
    PNOC["PNOC"]
    PNOC -->|"therapeutic target"| HCRTR1
    TRPC6["TRPC6"]
    TRPC6 -->|"therapeutic target"| HCRTR1
    HCRTR2 -->|"associated with"| HCRTR1
    DRD2["DRD2"]
    DRD2 -->|"activates"| HCRTR1
    HRH3["HRH3"]
    HRH3 -->|"activates"| HCRTR1
    HCRTR2 -->|"activates"| HCRTR1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| HCRTR1
    style HCRTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (226)

Target	Relation	Type	Str
Overall Survival	biomarker_for	phenotype	0.90
Relapse Free Survival	biomarker_for	phenotype	0.90
HCRTR2	associated_with	gene	0.90
CRF	interacts_with	protein	0.85
alcohol drinking	regulates	phenotype	0.85
Sleep-Wake Transition	associated_with	process	0.85
Sleep-Wake Transition	regulates	process	0.85
BDNF	inhibits	protein	0.85
cognitive dysfunction	promotes	phenotype	0.85
Interindividual Variability In Anesthetic Response	contributes_to	phenotype	0.82
Narcolepsy	implicated_in	disease	0.80
Loss Of Consciousness	associated_with	phenotype	0.80
therapeutic_target	therapeutic_target	process	0.80
lactate production	inhibits	process	0.80
Hemodynamic Stability	associated_with	phenotype	0.80
Time To Wake	associated_with	phenotype	0.80
BNST neuronal excitability	regulates	phenotype	0.80
Time To Loss Of Consciousness	associated_with	phenotype	0.80
orexin_receptor_1	encodes	protein	0.80
hemodynamic stability	regulates	phenotype	0.75
Breast Carcinoma	therapeutic_target	disease	0.75
autonomic function	regulates	process	0.75
Propofol	interacts_with	drug	0.75
sleep-wake transition	associated_with	biological_process	0.70
HCRTR2	interacts_with	gene	0.70
neurodegeneration	associated_with	disease	0.70
Ms	activates	disease	0.65
Als	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	inhibits	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Sleep Disorder	regulates	disease	0.65
Addiction	activates	disease	0.65
Ptsd	interacts_with	disease	0.65
Depression	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Sleep Disorder	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Als	inhibits	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Schizophrenia	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Depression	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	causes	disease	0.65

Incoming (107)

Source	Relation	Type	Str
Orexinergic Neurons	expressed_in	cell_type	0.92
HCRT	associated_with	gene	0.90
NEURON	interacts_with	cell_type	0.90
h-9e9fee95	targets	hypothesis	0.90
HCRTR2	interacts_with	gene	0.70
AND	expressed_in	gene	0.60
DNA	associated_with	gene	0.60
AND	inhibits	gene	0.60
OPRL1	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
AND	stabilizes	gene	0.60
DEPRESSION	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
SLEEP-WAKE CYCLE	associated_with	gene	0.60
BDNF	activates	entity	0.60
HCRT	interacts_with	gene	0.60
PNOC	associated_with	gene	0.60
HCRT	regulates	gene	0.60
GBM	activates	gene	0.60
CPLX3	activates	gene	0.60
ACE	interacts_with	gene	0.60
HCRT2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
AND	regulates	gene	0.60
AND	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
PER	inhibits	gene	0.60
MAPK	expressed_in	gene	0.60
GHRL	interacts_with	gene	0.60
ANXIETY	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	expressed_in	gene	0.60
BRCA	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
BDNF	inhibits	gene	0.60
CD4	expressed_in	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
OPRL1	biomarker_for	gene	0.60
MAPK	biomarker_for	gene	0.60
DRD2	activates	gene	0.60
HRH3	activates	gene	0.60
HCRTR2	activates	gene	0.60
ADRA1B	activates	gene	0.60
DRD1	activates	gene	0.60
GRIA1	activates	gene	0.60
ADRA1A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning HCRTR1 in their description or question text

No additional research found