| Gene Symbol | HIF |
| Full Name | 1α Protein |
| Subcellular Localization | </strong></td><td>Nucleus, Cytoplasm</td></tr> |
| GeneCards | HIF |
| Human Protein Atlas | HIF |
| Prolyl Hydroxylation Sites | Pro-402, Pro-564 (PHD regulation) |
| Asparaginyl Hydroxylation Site | Asn-803 (FIH regulation) |
| NLS | Nuclear localization signals |
| NES | Nuclear export signals |
| Gene Activation | Binds to hypoxia response elements (HRE) in target genes |
| Metabolic Adaptation | Increases glycolytic enzymes (GLUT1, HK, LDHA) |
| Angiogenesis | Promotes blood vessel formation |
| Erythropoiesis | Stimulates EPO production |
| Mitochondrial Control | Modulates mitochondrial biogenesis and dynamics |
| Ischemic Preconditioning | Protects against subsequent severe hypoxia |
| Associated Diseases | AD, ALI, Als, Alzheimer, AMI |
| Known Drugs/Compounds | quercetin, rapamycin |
| Interactions | ABCD3, AGING, AKK, AKT, AKT1, ALS |
| KG Connections | 1341 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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