concept

CHAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

21Outgoing

14Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CHAC2
Key Genes/Proteins	AND, CANCER, EIF4B, FERROPTOSIS, G3BP1, GENES
Related Diseases	Cancer, Gastric Cancer, Ms
Related Pathways	Ferroptosis

Pathway Diagram

graph TD
    CHAC2["CHAC2"]
    CHAC2 -->|"contributes to"| Peritoneal_Metastasis["Peritoneal Metastasis"]
    CHAC2 -->|"regulates"| Polyunsaturated_Lipids["Polyunsaturated Lipids"]
    CHAC2 -->|"activates"| Translation["Translation"]
    CHAC2 -->|"activates"| Tumor["Tumor"]
    CHAC2 -->|"activates"| Cancer["Cancer"]
    CHAC2 -->|"activates"| Ms["Ms"]
    CHAC2 -->|"activates"| CANCER["CANCER"]
    PABP1_eIF4B_Complex["PABP1/eIF4B Complex"] -->|"upregulates"| CHAC2
    Stress_Granules["Stress Granules"] -->|"activates"| CHAC2
    Hypoxia["Hypoxia"] -->|"activates"| CHAC2
    HIF["HIF"] -->|"activates"| CHAC2
    G3BP1["G3BP1"] -->|"activates"| CHAC2
    GENES["GENES"] -->|"activates"| CHAC2
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| CHAC2

Outgoing (21)

Target	Relation	Type	Str
Peritoneal Metastasis	contributes_to	phenotype	0.88
Polyunsaturated Lipids	regulates	compound	0.85
Peritoneal Metastasis	promotes	phenotype	0.85
Polyunsaturated Lipids	involved_in	compound	0.85
Polyunsaturated Lipid Metabolism	promotes	process	0.80
Translation	activates	process	0.80
Gastric Cancer	associated_with	disease	0.80
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
HIF-1Α	activates	gene	0.60
CANCER	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
AND	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Hif-1	activates	protein	0.60
EIF4B	activates	gene	0.60
PABP1	activates	gene	0.60
HIF	activates	gene	0.60
G3BP1	activates	gene	0.60
GENES	activates	gene	0.60

Incoming (14)

Source	Relation	Type	Str
PABP1/eIF4B Complex	upregulates	protein	0.92
PABP1/eIF4B Complex	activates	protein	0.90
PABP1	upregulates	protein	0.85
Stress Granules	activates	process	0.85
Hypoxia	activates	process	0.80
Hypoxia	upregulates	process	0.80
Stress Granule Formation	regulates	process	0.80
HIF-1Α	activates	gene	0.60
HIF	activates	gene	0.60
G3BP1	activates	gene	0.60
GENES	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
PABP1	activates	gene	0.60
EIF4B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHAC2 in their description or question text

No additional research found