| Gene Symbol | HIF |
| Full Name | 1α (Hypoxia-Inducible Factor 1-Alpha) |
| Subcellular Localization | </td><td>Nucleus, Cytoplasm</td></tr> |
| GeneCards | HIF |
| Human Protein Atlas | HIF |
| Asparagine hydroxylation | Factor inhibiting HIF (FIH) hydroxylates Asn803 in the C-TAD under moderate hypoxia, blocking p300 recruitment |
| Post-translational modifications | Phosphorylation (by GSK3β, MAPK), acetylation (by p300), and SUMOylation modulate stability and activity |
| Feedback regulation | HIF-1 induces PHD2 and PHD3 expression, creating a negative feedback loop that tunes the hypoxic response |
| Glycolysis upregulation | Induces GLUT1 (SLC2A1), hexokinases (HK1, HK2), phosphofructokinase (PFKL), and pyruvate dehydrogenase kinase 1 (PDK1), shifting energy production from oxidative phosphorylation to glycolysis |
| Angiogenesis | Induces VEGF (VEGFA) and VEGFR2 expression to promote new blood vessel formation |
| Erythropoiesis | Induces EPO (erythropoietin) to stimulate red blood cell production |
| Autophagy | Activates BNIP3 and other autophagy genes to promote cell survival under stress |
| Anti-apoptotic genes | Induces BCL2, survivin (BIRC5), and erythropoietin for direct neuroprotective effects |
| DNA repair genes | Upregulates genes involved in base excision repair and homologous recombination |
| Stress response genes | Activates HO-1 (heme oxygenase 1) and other antioxidant response genes |
| Associated Diseases | AD, ALI, Als, Alzheimer, AMI |
| Known Drugs/Compounds | quercetin, rapamycin |
| Interactions | ABCD3, AGING, AKK, AKT, AKT1, ALS |
| KG Connections | 1348 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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