Contents

FYCO1 — FYVE and Coiled-Coil Domain Containing 1

🧬 Gene Info

Gene Symbol	FYCO1
Full Name	FYVE and Coiled-Coil Domain Containing 1
Chromosome	3p21.2
Function	FYCO1 encodes a autophagy adapter protein that links autophagosomes to the microtubule-based transport machinery.
Primary Expression	the lens, and mutations cause congenital cataract, often accompanying spastic paraplegia in SPG59
Pathways	mTOR, mtor
UniProt ID	Q9BQR1
NCBI Gene ID	79443
Ensembl ID	ENSG00000164120
OMIM	607781
GeneCards	FYCO1
Human Protein Atlas	FYCO1
FYVE domain	binds to phosphatidylinositol 3-phosphate (PI3P) on autophagosomal membranes
Coiled-coil domains	mediate protein-protein interactions
LC3-interacting region (LIR)	binds LC3/GABARAP proteins
Associated Diseases	Cancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AND, APOPTOSIS, AR, ATG
KG Connections	170 knowledge graph edges
Databases	GeneCards HPA STRING

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