| Gene Symbol | FOXO3 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | FOXO3-targeting drugs modulate the PI3K/Akt/FOXO3 signaling pathway to promote FOXO3 nuclear translocation and transcriptional activity, enhancing autophagy, stress resistance, and apoptosis in can... |
| Mechanism of Action | FOXO3-targeting drugs modulate the PI3K/Akt/FOXO3 signaling pathway to promote FOXO3 nuclear translocation and transcriptional activity, enhancing autophagy, stress resistance, and apoptosis in cancer cells. Indirect activators increase FOXO3 expression or prevent its degradation, thereby amplifying cellular protective responses. |
| Subcellular Localization | ** | Nucleus (active), cytoplasm (inactive) | |
| Druggability | Low (0.42) |
| Clinical Stage | Approved |
| Molecular Weight | 71 kDa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone |
| UniProt ID | O43524 |
| Ensembl ID | ENSG00000118445 |
| GeneCards | FOXO3 |
| Human Protein Atlas | FOXO3 |
| Associated Diseases | Aging, Als, Alzheimer, AUTOPHAGY, Cancer |
| Known Drugs/Compounds | DEFERIPRONE, rapamycin, RAPAMYCIN, Ros, trehalose, TREHALOSE |
| Interactions | AD, AGING, AKT, ALOX15, ALS, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | FOXO3-Longevity Pathway Epigenetic Reprogramming |
| KG Connections | 1004 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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