Contents

FOXO1 Gene

🧬 Gene Info

Gene Symbol	FOXO1
Full Name	Forkhead Box O1
Aliases	Forkhead Box O1 transcription factor
Chromosome	13q14.11
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	It functions as both an activator and repressor depending on cellular context and interacting partners.
Mechanism of Action	Small molecule modulation of protein-DNA interactions or cofactor binding
Druggability	Medium (0.55)
Clinical Stage	Phase I
Molecular Weight	70 kDa
Amino Acids	655 aa
Exons	4 coding exons
Pathways	PI3K
UniProt ID	Q12778
NCBI Gene ID	2308
Ensembl ID	ENSG00000150907
OMIM	136351
GeneCards	FOXO1
Human Protein Atlas	FOXO1
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compounds	Cinobufagin, Epigallocatechin gallate, MELATONIN, METFORMIN, rapamycin, RAPAMYCIN
Interactions	ACOX1, Actin, Adiponectin, ADIPOQ, AGING, AKT
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Transcriptional Autophagy-Lysosome Coupling
KG Connections	1261 knowledge graph edges
Databases	GeneCards HPA STRING

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