gene 3,329 words KG: FOXO4
Contents

FOXO4 — Forkhead Box O4

🧬 Gene Info
Gene SymbolFOXO4
Full NameForkhead Box O4
ChromosomeXq13.1
Protein FamilyForkhead box O family
Protein TypeTranscription Factor
Functionis a transcription factor belonging to the FOX O subfamily of Forkhead box proteins.
Primary Expressionvarious tissues with particularly high levels in:
Molecular Weight59.6 kDa
Amino Acids556 aa
Exons4
PathwaysPI3K
UniProt IDP98177
NCBI Gene ID8941
Ensembl IDENSG00000124780
OMIM300434
GeneCardsFOXO4
Human Protein AtlasFOXO4
Associated DiseasesAls
InteractionsActin, AKT, AMPK, AUTOPHAGY, CAMKII, CBL
KG Connections74 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Autophagosome Maturation Checkpoint Control
Score: 0.71
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
CBL Gene
gene · KG edge: activates
FOXA2 — Forkhead Box A2
gene · KG edge: associated_with
FOXG1 — Forkhead Box G1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

AKT activates FOXO4
CBL activates FOXO4
FOXA2 associated_with FOXO4
FOXO6 associated_with FOXO4
FOXO3 associated_with FOXO4
FOXP3 associated_with FOXO4
FOXG1 associated_with FOXO4
SHH expressed_in FOXO4
FOXP1 associated_with FOXO4
FOXM1 associated_with FOXO4

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