Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VEGF-B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | VEGF-B |
| Key Genes/Proteins | AND, ATF4, AUTOPHAGY, DIABETES MELLITUS, Erk, FGFR1 |
| Related Diseases | Cardiomyopathy, Diabetes |
| Related Pathways | Autophagy |
graph TD
VEGF_B["VEGF-B"]
VEGF_B -->|"binds_to"| FGFR1["FGFR1"]
VEGF_B -->|"promotes"| FGFR1_VEGFR1_complex_formation["FGFR1/VEGFR1 complex formation"]
VEGF_B -->|"inhibits"| ERK_activation["ERK activation"]
VEGF_B -->|"inhibits"| angiogenesis["angiogenesis"]
VEGF_B -->|"interacts"| GRP78["GRP78"]
VEGF_B -->|"inhibits"| Diabetes["Diabetes"]
VEGF_B -->|"activates"| Cardiomyopathy["Cardiomyopathy"]
VEGF_B -->|"inhibits"| PERK["PERK"]
Melatonin["Melatonin"] -->|"downregulates"| VEGF_B
VEGF["VEGF"] -->|"inhibits"| VEGF_B
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| VEGF_B
RNA["RNA"] -->|"interacts"| VEGF_B
AND["AND"] -->|"inhibits"| VEGF_B
ATF4["ATF4"] -->|"inhibits"| VEGF_B
PERK -->|"inhibits"| VEGF_B| Target | Relation | Type | Str |
|---|---|---|---|
| FGFR1 | binds_to | protein | 0.95 |
| FGFR1/VEGFR1 complex formation | promotes | process | 0.95 |
| ERK activation | inhibits | process | 0.93 |
| angiogenesis | inhibits | process | 0.92 |
| GRP78 | interacts_with | protein | 0.85 |
| Cardiomyopathy | activates | disease | 0.65 |
| Diabetes | inhibits | disease | 0.65 |
| DIABETES MELLITUS | inhibits | gene | 0.60 |
| PERK | inhibits | gene | 0.60 |
| ATF4 | inhibits | gene | 0.60 |
| Vegf | inhibits | protein | 0.60 |
| Erk | inhibits | protein | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Autophagy | protects_against | pathway | 0.60 |
| Cardiomyocyte | protects_against | cell_type | 0.60 |
| Endothelial | associated_with | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VEGF-B in their description or question text
No additional research found