gene 528 words KG: FGFR1
Contents

FGFR1 — Fibroblast Growth Factor Receptor 1

🧬 Gene Info
Gene SymbolFGFR1
Full NameFibroblast Growth Factor Receptor 1
Chromosome8p11
FunctionFGFR1 encodes fibroblast growth factor receptor 1, a receptor tyrosine kinase that binds multiple FGF ligands (FGF1, FGF2, FGF4, etc.).
Primary Expressionneural stem cells, neurons, and astrocytes
PathwaysMAPK, PI3K
UniProt ID[P11362](https://www.uniprot.org/uniprot/P11362)
Ensembl IDENSG00000077782
OMIM136350
GeneCardsFGFR1
Human Protein AtlasFGFR1
Associated DiseasesAls, Cancer, epilepsy, Glioblastoma
InteractionsAGING, AKT, AKT3, AMPK, AND, APOPTOSIS
KG Connections230 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AKT3 Gene
gene · KG edge: associated_with
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HSPG2 activates FGFR1
FGFR1 interacts_with FGF2
FGF1 activates FGFR1
FGFR1 activates adipogenesis
FGF1 regulates FGFR1
FGFR1 regulates PIEZO1
FGFR1 therapeutic_target SOX2
FGFR1 therapeutic_target CDK4
FGFR1 therapeutic_target RB1
FGFR1 therapeutic_target CDKN2A

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