Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CALMODULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CALMODULIN |
| Key Genes/Proteins | BDNF |
graph TD
CALMODULIN["CALMODULIN"]
CALMODULIN -->|"regulates"| Als["Als"]
CALMODULIN -->|"activates"| Depression["Depression"]
CALMODULIN -->|"expressed in"| Stroke["Stroke"]
CALMODULIN -->|"inhibits"| Ischemia["Ischemia"]
CALMODULIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
CALMODULIN -->|"activates"| Mtor["Mtor"]
CALMODULIN -->|"inhibits"| Blood_Brain_Barrier["Blood-Brain Barrier"]
CAMKII["CAMKII"] -->|"regulates"| CALMODULIN
AXON["AXON"] -->|"regulates"| CALMODULIN
CALCINEURIN["CALCINEURIN"] -->|"regulates"| CALMODULIN
MTOR["MTOR"] -->|"activates"| CALMODULIN
CHR2["CHR2"] -->|"activates"| CALMODULIN
DEPRESSION["DEPRESSION"] -->|"activates"| CALMODULIN
EEF2["EEF2"] -->|"activates"| CALMODULIN| Target | Relation | Type | Str |
|---|---|---|---|
| AMPK | mediates | protein | 0.85 |
| BDNF | modulates | protein | 0.80 |
| Neurodegeneration | protects_against | process | 0.80 |
| Ischemia | inhibits | disease | 0.60 |
| Neurodegeneration | regulates | disease | 0.60 |
| Als | regulates | disease | 0.60 |
| Depression | activates | disease | 0.60 |
| Stroke | expressed_in | disease | 0.60 |
| Blood-Brain Barrier | inhibits | pathway | 0.55 |
| Mtor | activates | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRIM1-269aa | associated_with | protein | 0.90 |
| CALCINEURIN | regulates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| CHR2 | activates | gene | 0.60 |
| EEF2 | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| CAV1 | regulates | gene | 0.60 |
| CAMKII | regulates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| CAMKII | activates | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| STROKE | expressed_in | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Calmodulin isoform switching from CaMK to calcineurin activa | 0.607 | neurodegeneration | What determines the specificity of calci |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CALMODULIN in their description or question text
No additional research found