gene

EEF2K

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EEF2K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

17Outgoing

10Incoming

0Experiments

0Debates

Summary

Page for EEF2K — Eukaryotic Elongation Factor 2 Kinase

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🧬 Gene Info

Gene Symbol	EEF2K
Full Name	Eukaryotic Elongation Factor 2 Kinase
Chromosome	16p13.3
Protein Type	Kinase
Function	is a unique calcium/calmodulin-dependent kinase that regulates protein synthesis by phosphorylating eukaryotic elongation factor 2 (eEF2).
Primary Expression	human tissues, with particular importance in the brain where it regulates translation elongation in response to cellular signals
Subcellular Localization	both the cell body and dendritic compartments, where it regulates local translation in response to synaptic activity
Amino Acids	724 aa
Pathways	AMPK, mTOR, MAPK Pathway
Ensembl ID	ENSG00000103319
GeneCards	EEF2K
Human Protein Atlas	EEF2K
Calcium/Calmodulin Binding	Primary activation mechanism
AMP-Activated Protein Kinase (AMPK)	Phosphorylates and activates EEF2K during energy stress
mTORC1 Signaling	Inhibits EEF2K through S6K-mediated phosphorylation
Associated Diseases	neurodegeneration
Interactions	AND, AUTOPHAGY, BDNF, CANCER, CYTOKINES, DEPRESSION
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EEF2K — Eukaryotic Elongation Factor 2 Kinase

gene · 1026 words

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Pathway Diagram

graph TD
    EEF2K["EEF2K"]
    EEF2["EEF2"]
    AUTOPHAGY_GENE["AUTOPHAGY"]
    LC3["LC3"]
    Autophagy_Pathway["Autophagy Pathway"]
    BDNF["BDNF"]
    NLRP3["NLRP3"]
    CYTOKINES["CYTOKINES"]
    GFAP["GFAP"]
    Neuroinflammation["Neuroinflammation"]
    Depression["Depression"]
    ALS["ALS"]
    HDAC1["HDAC1"]
    Neurodegeneration["Neurodegeneration"]

    BDNF -->|"regulates"| EEF2K
    NLRP3 -->|"inhibits"| EEF2K
    CYTOKINES -->|"inhibits"| EEF2K
    GFAP -->|"activates"| EEF2K

    EEF2K -->|"inhibits"| EEF2
    EEF2K -->|"inhibits"| AUTOPHAGY_GENE
    EEF2K -->|"inhibits"| LC3
    EEF2K -->|"inhibits"| Autophagy_Pathway
    EEF2K -->|"inhibits"| HDAC1
    EEF2K -->|"regulates"| BDNF

    EEF2K -->|"activates"| Neuroinflammation
    EEF2K -->|"activates"| Depression
    EEF2K -->|"inhibits"| ALS
    EEF2K -->|"implicated in"| Neurodegeneration

    style EEF2K fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style BDNF fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NLRP3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style CYTOKINES fill:#4a1a6b,stroke:#333,stroke-width:2px
    style GFAP fill:#4a1a6b,stroke:#333,stroke-width:2px
    style EEF2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style AUTOPHAGY_GENE fill:#1b5e20,stroke:#333,stroke-width:2px
    style LC3 fill:#1b5e20,stroke:#333,stroke-width:2px
    style Autophagy_Pathway fill:#1b5e20,stroke:#333,stroke-width:2px
    style HDAC1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style Neuroinflammation fill:#ef5350,stroke:#333,stroke-width:2px
    style Depression fill:#7d4200,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style Neurodegeneration fill:#ef5350,stroke:#333,stroke-width:2px

Outgoing (17)

Target	Relation	Type	Str
peptide chain elongation	inhibits	process	0.95
pain-associated behaviors	promotes	phenotype	0.91
BDNF	regulates	protein	0.88
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
AUTOPHAGY	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
DEPRESSION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
BDNF	regulates	gene	0.60
EEF2	inhibits	gene	0.60
LC3	inhibits	gene	0.60
HDAC1	inhibits	gene	0.60

Incoming (10)

Source	Relation	Type	Str
noxious stimuli	activates	process	0.94
EEF2	inhibits	gene	0.90
BDNF	regulates	gene	0.60
NLRP3	inhibits	gene	0.60
BDNF	activates	gene	0.60
GFAP	activates	gene	0.60
SNAP25	activates	gene	0.60
PSD95	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EEF2K in their description or question text

No additional research found