Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ptsd: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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graph TD
ptsd["ptsd"]
ANXIETY(["ANXIETY"])
ptsd -->|"associated_with"| ANXIETY
Covid{"Covid"}
ptsd -->|"associated_with"| Covid
CRHR1(["CRHR1"])
ptsd -->|"activates"| CRHR1
NEURONS["NEURONS"]
ptsd -->|"activates"| NEURONS
GAIN(["GAIN"])
ptsd -->|"associated_with"| GAIN
Hippocampus["Hippocampus"]
ptsd -->|"regulates"| Hippocampus
DEPRESSION{"DEPRESSION"}
DEPRESSION -->|"associated_with"| ptsd
style ptsd fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#ef5350| Target | Relation | Type | Str |
|---|---|---|---|
| Alcohol Use Disorder | associated_with | disease | 0.95 |
| amygdala | affects | brain_region | 0.80 |
| hippocampus | affects | brain_region | 0.80 |
| neurons | affects | cell_type | 0.70 |
| cortex | affects | brain_region | 0.70 |
| synaptic plasticity | involves | pathway | 0.60 |
| microglia | affects | cell_type | 0.60 |
| neural stem cells | affects | cell_type | 0.60 |
| prefrontal cortex | affects | brain_region | 0.60 |
| mast cells | affects | cell_type | 0.60 |
| cerebellum | affects | brain_region | 0.60 |
| neuropeptide Y | disrupts | neurotransmitter | 0.60 |
| oxytocin | disrupts | neurotransmitter | 0.60 |
| ferroptosis | involves | pathway | 0.60 |
| dentate gyrus | affects | brain_region | 0.60 |
| STING | causes | gene | 0.60 |
| Dentate Gyrus | associated_with | brain_region | 0.55 |
| Mast Cell | activates | cell_type | 0.55 |
| Cerebellum | associated_with | brain_region | 0.55 |
| Blood-Brain Barrier | associated_with | pathway | 0.55 |
| Neuron | associated_with | cell_type | 0.55 |
| Dna Methylation | associated_with | pathway | 0.55 |
| Er Stress | associated_with | pathway | 0.55 |
| Blood-Brain Barrier | activates | pathway | 0.55 |
| Microglia | activates | cell_type | 0.55 |
| T Cell | activates | cell_type | 0.55 |
| Epigenetic | associated_with | pathway | 0.55 |
| Hypothalamus | associated_with | brain_region | 0.55 |
| Neuron | inhibits | cell_type | 0.55 |
| Oxidative Phosphorylation | associated_with | pathway | 0.55 |
| Hippocampus | associated_with | brain_region | 0.55 |
| Thalamus | associated_with | brain_region | 0.55 |
| Alzheimer'S Disease | interacts_with | disease | 0.50 |
| FKBP5 | interacts_with | concept | 0.50 |
| HCRTR1 | interacts_with | gene | 0.50 |
| ALZHEIMER | interacts_with | gene | 0.50 |
| NR3C1 | interacts_with | gene | 0.50 |
| ALZHEIMER'S | interacts_with | concept | 0.50 |
| disease | associated_with | disease | 0.50 |
| Cortex | activates | brain_region | 0.50 |
| Hippocampus | activates | entity | 0.50 |
| CEREBELLUM | activates | concept | 0.50 |
| AMYGDALA | activates | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| AMYGDALA | associated_with | concept | 0.50 |
| CRHR1 | activates | gene | 0.50 |
| disease | interacts_with | disease | 0.50 |
| GAIN | associated_with | gene | 0.50 |
| ANXIETY | associated_with | gene | 0.50 |
| Covid | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Ketamine-Aln | treats | drug | 0.95 |
| stress_response | risk_factor_for | pathway | 0.70 |
| HCN1 | regulates | gene | 0.70 |
| MICROGLIA | activates | gene | 0.65 |
| RNA | associated_with | gene | 0.65 |
| ALZHEIMER | associated_with | gene | 0.65 |
| DNA | associated_with | gene | 0.65 |
| AMYLOID | activates | gene | 0.65 |
| ALZHEIMER | activates | gene | 0.65 |
| ANXIETY | associated_with | gene | 0.65 |
| DEPRESSION | associated_with | gene | 0.65 |
| CALCA | inhibits | gene | 0.65 |
| CRH | inhibits | gene | 0.65 |
| NR3C1 | inhibits | gene | 0.65 |
| CRHR1 | inhibits | gene | 0.65 |
| RAMP1 | inhibits | gene | 0.65 |
| IL18BP | inhibits | gene | 0.65 |
| BDNF | inhibits | gene | 0.65 |
| FKBP5 | inhibits | gene | 0.65 |
| IL18 | inhibits | gene | 0.65 |
| GAIN | associated_with | gene | 0.65 |
| MET | associated_with | gene | 0.65 |
| ANXIETY | protects_against | gene | 0.65 |
| MITOCHONDRIA | associated_with | gene | 0.65 |
| GHRL | interacts_with | gene | 0.65 |
| CRH | associated_with | gene | 0.65 |
| AVP | associated_with | gene | 0.65 |
| NR3C1 | associated_with | gene | 0.65 |
| POMC | associated_with | gene | 0.65 |
| FKBP5 | associated_with | gene | 0.65 |
| CRH | activates | gene | 0.65 |
| HCRTR1 | interacts_with | gene | 0.65 |
| HCRTR2 | associated_with | gene | 0.65 |
| HAPLN1 | associated_with | gene | 0.65 |
| P2RY12 | associated_with | gene | 0.65 |
| CCR5 | associated_with | gene | 0.65 |
| GRM2 | associated_with | gene | 0.65 |
| CDH23 | associated_with | gene | 0.65 |
| CRH | inhibits | entity | 0.60 |
| CRHR1 | inhibits | entity | 0.60 |
| Rb | protects_against | protein | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| NR3C1 | associated_with | gene | 0.60 |
| HCRTR1 | interacts_with | gene | 0.60 |
| DEPRESSION | protects_against | entity | 0.60 |
| ALZHEIMER'S | associated_with | disease | 0.60 |
| Ghrelin | associated_with | protein | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.60 |
| PREFRONTAL | regulates | brain_region | 0.60 |
| FRONTAL | regulates | brain_region | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
spatial memory | 2026-04-08 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ptsd in their description or question text
No additional research found