concept

COGNITION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

8Hypotheses

0Analyses

2Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	COGNITION
Key Genes/Proteins	CYP46A1
Related Diseases	STROKE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AAIC 2026 — Vascular Contributions to Cognitive Impairment and Dementia

event · 514 words

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Pathway Diagram

graph TD
    COGNITION["COGNITION"]
    COGNITION -->|"interacts"| Prefrontal_Cortex["Prefrontal Cortex"]
    APOE4["APOE4"] -->|"inhibits"| COGNITION
    Gut_Microbiota["Gut Microbiota"] -->|"modulates"| COGNITION
    Dopaminergic_Circuits["Dopaminergic Circuits"] -->|"regulates"| COGNITION
    LCPUFA_Supplementation["LCPUFA Supplementation"] -.protects against.-> COGNITION
    BDNF["BDNF"] -->|"mediates"| COGNITION
    Dentate_Gyrus["Dentate Gyrus"] -->|"involved_in"| COGNITION
    Caffeine["Caffeine"] -->|"modulates"| COGNITION
    ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"] -->|"regulates"| COGNITION

Outgoing (2)

Target	Relation	Type	Str
Prefrontal Cortex	associated_with	entity	0.70
Prefrontal Cortex	interacts_with	entity	0.70

Incoming (53)

Source	Relation	Type	Str
BDNF	regulates	gene	0.90
Dopaminergic Circuits	regulates	pathway	0.90
Oveporexton	associated_with	drug	0.90
Narcolepsy Type 1	associated_with	disease	0.90
Alzheimer'S Disease	causes	disease	0.90
Exercise	associated_with	process	0.90
APOE4	inhibits	protein	0.90
Gut Microbiota	modulates	process	0.90
Urolithin A	associated_with	compound	0.90
STROKE	causes	disease	0.90
Dentate Gyrus	involved_in	cell_type	0.85
LCPUFA	protects_against	compound	0.85
Perinatal Lcpufa Supplementation	treats	drug	0.85
CI-994	upregulates	drug	0.85
LCPUFA Supplementation	protects_against	compound	0.85
ADENOSINE RECEPTORS	regulates	receptor	0.85
TFEB	promotes	gene	0.85
Gut-Brain Axis	modulates	pathway	0.85
COMT	regulates	gene	0.85
BDNF	mediates	entity	0.85
PKN1-N207	associated_with	protein	0.85
BDNF	associated_with	protein	0.85
Caffeine	modulates	compound	0.85
BDNF	regulates	gene	0.85
resistance exercise	associated_with	process	0.85
BDNF	enhances	gene	0.80
BDNF	influences	gene	0.80
TET2	modulates	protein	0.80
GLP-1	improves	protein	0.80
exercise	associated_with	process	0.80
irisin	promotes	protein	0.80
Neurodegenerative Diseases	causes	disease	0.80
No Donors	modulates	drug	0.75
Unfolded Protein Response	associated_with	pathway	0.75
Sleep	correlates_with	phenotype	0.75
Methylene Blue	associated_with	drug	0.75
BDNF	regulates	protein	0.72
Methylene Blue	upregulates	drug	0.70
Alzheimer's disease	causes	disease	0.70
BDNF	activates	protein	0.70
Prefrontal Cortex	activates	entity	0.70
Prefrontal Cortex	associated_with	entity	0.70
Prefrontal Cortex	interacts_with	entity	0.70
Prefrontal Cortex	inhibits	entity	0.70
dopaminergic_circuits	regulates	pathway	0.64
prefrontal_cortex	regulates	brain_region	0.64
AQP4	associated_with	protein	0.60
CYP46A1	associated_with	gene	0.60
COMT	regulates	protein	0.60
BDNF	involved_in	protein	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective blockade of classical-pathway activation downstrea	0.750	neurodegeneration	Does C1q function differ based on subcel
Exposed amyloidogenic segments (β-sheet propensity residues)	0.740	protein biochemistry	Do chaperones selectively recognize path
Autophagic Receptor Sequestration via K63-Ub 'Signalone' Rec	0.720	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascad	0.648	neurodegeneration	How do pathological stress granules in n
J-protein co-chaperone repertoire enables selective recognit	0.620	protein biochemistry	Do chaperones selectively recognize path

Multi-Chaperone System Co-Activation Prevents Saturation Thr	0.560	protein folding	Can chaperone enhancement approaches ove
TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocy	0.453	neuroinflammation	What molecular mechanisms enable microgl
Paraneoplastic myelopathies involve CD8+ T cell recognition	0.450	neuroinflammation	What are the specific pathophysiological

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity