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protein 2,550 words KG: PRKDCPROTEIN
Contents

DNA-PKcs (PRKDC) Protein

🔬 Protein Info
Gene SymbolDNA
Full NameDependent Protein Kinase Catalytic Subunit (DNA-PKcs)
Functionis an epigenetic modification that regulates gene expression without changing the DNA sequence.
Subcellular Localization** | Nucleus (nuclear matrix), cytoplasm |
PathwaysAMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis
GeneCardsDNA
Human Protein AtlasDNA
Associated DiseasesAD, Addiction, aging, ALI, Als
Known Drugs/Compoundsketamine, metformin, rapamycin, resveratrol, valproic acid
InteractionsA2M, ABCB1, ABCD3, ACETYL-COA, ACTB, Actin
KG Connections5276 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · completedWhat determines the specificity of DDR protein recruitment t
neurodegeneration · completedHow do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (30)

Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
exploratory · proposed · Score: 0.90Epigenetic clocks association with brain aging patterns in o
exploratory · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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