gene 2,823 words KG: ZBP1
Contents

ZBP1 (Z-DNA Binding Protein 1)

🧬 Gene Info
Gene SymbolZBP1
Aliasesnecroptosis, PANoptosis
Chromosome6p24.1
Functionis a cytosolic nucleic acid sensor that plays critical roles in innate immune responses, regulated cell death pathways, and inflammation[@takaoka2007; @kuriakose2023].
Molecular Weight46 kDa
Amino Acids429 aa
PathwaysApoptosis, Autophagy, Complement, Epigenetic, Immune Response
UniProt IDQ9H171
NCBI Gene ID23073
Ensembl IDENSG00000185730
GeneCardsZBP1
Human Protein AtlasZBP1
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Atherosclerosis, Inflammation
InteractionsABCG2, Actin, ADAR1, AIM2, ALZHEIMER, AMYLOID
KG Connections400 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Cross-Seeding Prevention Strategy
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (7)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

BAX activates ZBP1
DRP1 activates ZBP1
FADD activates ZBP1
NRF2 activates ZBP1
ABCG2 activates ZBP1
ZBP1 activates MFN2
ZBP1 activates GSDMD
ZBP1 activates RIPK1
ZBP1 activates RAB7A
ZBP1 activates CAT

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