gene 3,528 words KG: DNAJC13
Contents

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

🧬 Gene Info
Gene SymbolDNAJC13
Full NameDnaJ Heat Shock Protein Family Member C13
AliasesRME-8
Chromosome3q22.1
Protein TypeChaperone
Functionis a co-chaperone protein primarily localized to endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control.
Primary Expressionneurons throughout the brain, particularly in dopaminergic neurons of the substantia nigra pars compacta
Subcellular Localizationendosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control. Ori
Molecular Weight280 kDa
Amino Acids558 aa
Exons33
PathwaysmTOR, mtor
GeneCardsDNAJC13
Human Protein AtlasDNAJC13
Early endosomesColocalizes with EEA1 and Rab5
Associated DiseasesAls, Alzheimer, Parkinson, PARKINSON DISEASE, Parkinson's disease
KG Connections64 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

ATP1A3 Gene - Sodium-Potassium ATPase Alpha 3
gene · KG edge: associated_with
VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C
gene · KG edge: associated_with
GBA1 (Redirect)
redirect · KG edge: associated_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: associated_with
GCH1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GCH1 associated_with DNAJC13
VPS35 associated_with DNAJC13
GBA1 associated_with DNAJC13
TARDBP associated_with DNAJC13
PARK7 associated_with DNAJC13
DNAJC13 associated_with FBXO7
DNAJC13 associated_with PINK1
DNAJC13 associated_with VPS13C
DNAJC13 associated_with DNAJC6
DNAJC13 associated_with ATP13A2

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