gene 711 words KG: CYP3A4
Contents

CYP3A4 — Cytochrome P450 3A4

🧬 Gene Info
Gene SymbolCYP3A4
Full NameCytochrome P450 3A4
Chromosome7q21.1
FunctionCYP3A4 encodes cytochrome P450 3A4, which plays a critical role in
Primary Expressionthe liver and intestinal mucosa
PathwaysOxidative Stress
UniProt ID[P08684](https://www.uniprot.org/uniprot/P08684)
Ensembl IDENSG00000123338
OMIM171696
GeneCardsCYP3A4
Human Protein AtlasCYP3A4
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Anxiety
Known Drugs/Compoundsanxiolytic drugs
InteractionsABCB1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, BID, CCL2
KG Connections293 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Noradrenergic-Tau Propagation Blockade
Score: 0.71
APOE-Dependent Autophagy Restoration
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Flotillin-1 Stabilization Compounds
Score: 0.68
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
pg 1/2Next →

Related Analyses (13)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

See Also (6)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CYP3A4 regulates MTOR
MAOB associated_with CYP3A4
GABRA1 associated_with CYP3A4
CHAT associated_with CYP3A4
HMGCR associated_with CYP3A4
OPRM1 associated_with CYP3A4
SLC30A8 associated_with CYP3A4
COMT associated_with CYP3A4
NBEA associated_with CYP3A4
HTR2C associated_with CYP3A4

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.