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gene 648 words KG: CNR1
Contents

CNR1 Gene

🧬 Gene Info
Gene SymbolCNR1
Full NameCannabinoid Receptor 1
Chromosome6q25.2
FunctionThe CNR1 gene encodes the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor that is the most abundant cannabinoid receptor in the brain.
Molecular Weight53 kDa
PathwaysMAPK pathway
UniProt IDP21554
NCBI Gene ID1268
Ensembl IDENSG00000118432
OMIM114010
GeneCardsCNR1
Human Protein AtlasCNR1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, depression, neurodegeneration
Known Drugs/Compoundscannabinoids
InteractionsAKT, ALZHEIMER, ANXIETY, AR, BDNF, DEPRESSION
KG Connections220 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90Conditional CB1R knockout in mPFC CaMKIIα neurons
validation · proposed · Score: 0.90Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85CB1R expression mapping in mPFC-vlPAG circuit
exploratory · proposed · Score: 0.85Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: causesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: expressed_inACTB Gene
gene · KG edge: regulatesAKT1 Gene
gene · KG edge: causesBIN1 — Bridging Integrator 1
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

EPAS1 therapeutic_target CNR1
CACNG6 therapeutic_target CNR1
BIN1 therapeutic_target CNR1
CHRNA2 therapeutic_target CNR1
CEBPA therapeutic_target CNR1
CNR1 therapeutic_target CTSD
CNR1 therapeutic_target NME1
CNR1 therapeutic_target CACNA1E
CNR1 therapeutic_target CACNA2D3
CNR1 therapeutic_target PRKAB1

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