gene

ATF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATF6 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 303 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATF6
Full Name	Activating Transcription Factor 6
Chromosome	1q22.1
Function	is a Type II transmembrane protein that serves as a critical endoplasmic reticulum (ER) stress sensor and transcriptional activator.
Molecular Weight	90 kDa
Pathways	Akt, Autophagy, Lipid Metabolism, Mapk, Mtor
UniProt ID	[Q09470](https://www.uniprot.org/uniprot/Q09470)
Ensembl ID	ENSG00000118260
OMIM	604436
GeneCards	ATF6
Human Protein Atlas	ATF6
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compounds	rapamycin
Interactions	AKT, AKT1, AKT1S1, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections	427 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF6["ATF6"] -->|"interacts"| Cancer["Cancer"]
    ATF6["ATF6"] -->|"interacts"| Als["Als"]
    ATF6["ATF6"] -->|"interacts"| Ms["Ms"]
    ATF6["ATF6"] -->|"regulates"| Fibrosis["Fibrosis"]
    ATF6["ATF6"] -->|"activates"| Ms_1["Ms"]
    ATF6["ATF6"] -->|"activates"| Als_2["Als"]
    OPTN["OPTN"] -->|"interacts"| ATF6["ATF6"]
    CASP3["CASP3"] -->|"regulates"| ATF6["ATF6"]
    AKT1["AKT1"] -->|"regulates"| ATF6["ATF6"]
    CALCOCO2["CALCOCO2"] -->|"regulates"| ATF6["ATF6"]
    style ATF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (290)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATF6	data_in	dataset_row	0.00
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
CANCER	activates	gene	0.70
Mtor	activates	pathway	0.70
Hepatitis	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	associated_with	disease	0.65
Arthritis	activates	disease	0.65
Huntington	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Ms	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
ALS	interacts_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	regulates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
Autoimmune	activates	disease	0.65
Parkinson	activates	disease	0.65

Incoming (140)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATF6	data_in	dataset_row	0.00
CAMK2D	upregulates	gene	0.80
ERN1	activates	gene	0.60
EIF2AK3	activates	gene	0.60
DEPTOR	interacts_with	gene	0.60
GENES	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
LC3B	activates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CANCER	inhibits	gene	0.60
CYTOKINES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NF-ΚB	regulates	gene	0.60
MIR-9-5P	regulates	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
ROS	regulates	gene	0.60
DNA	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
ATG	regulates	gene	0.60
AND	regulates	gene	0.60
AMPK	activates	entity	0.60
HSPA5	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
TREM2	activates	gene	0.60
AKT1	inhibits	gene	0.60
RAB7A	regulates	gene	0.60
YAP1	activates	gene	0.60
RICTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATF6 in their description or question text

No additional research found