gene 2,364 words KG: ATF6
Contents

ATF6 - Activating Transcription Factor 6

🧬 Gene Info
Gene SymbolATF6
Full NameActivating Transcription Factor 6
Chromosome1q22.1
Functionis a Type II transmembrane protein that serves as a critical endoplasmic reticulum (ER) stress sensor and transcriptional activator.
Molecular Weight90 kDa
PathwaysAkt, Autophagy, Lipid Metabolism, Mapk, Mtor
UniProt ID[Q09470](https://www.uniprot.org/uniprot/Q09470)
Ensembl IDENSG00000118260
OMIM604436
GeneCardsATF6
Human Protein AtlasATF6
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/Compoundsrapamycin
InteractionsAKT, AKT1, AKT1S1, ALZHEIMER'S DISEASE, AMPK, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections425 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability in CJD
clinical · proposed · Score: 0.40

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
AKT1 Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: regulates
APC Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

ATF6 interacts_with MLKL
ATF6 interacts_with DEPTOR
ATF6 interacts_with HMGB1
ATF6 interacts_with EGF
ATF6 interacts_with MLST8
ATF6 interacts_with RICTOR
ATF6 interacts_with MTOR
ATF6 interacts_with PIK3C3
ATF6 interacts_with EGFR
ATF6 interacts_with PPARG

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