disease

autism spectrum disorder

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about autism spectrum disorder: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

1Analyses

12Outgoing

50Incoming

0Experiments

1Debates

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Disease Info

Category	Genetic/Complex
Associated Genes	ADNP, ALS, ARID1B, ARNTL, C2, CIC, CLOCK, CYP19A1
Therapeutic Agents	curcumin, rapamycin
KG Connections	175 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| apoptosis_pathway["apoptosis pathway"]
    style apoptosis_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ubiquitin_proteasome["ubiquitin-proteasome"]
    style ubiquitin_proteasome fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| MAPK_signaling["MAPK signaling"]
    style MAPK_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    autism_spectrum_disorder["autism spectrum disorder"] -->|"involves"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Disease_Associated_Microglia["Disease-Associated Microglia"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Disease_Associated_Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tuberous_Sclerosis_Complex_Ass["Tuberous Sclerosis Complex-Associated Epilepsy"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Tuberous_Sclerosis_Complex_Ass fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"associated"| autism_spectrum_disorder["autism spectrum disorder"]
    style Microbiota_Gut_Brain_Axis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ROS["ROS"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
    style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NLRP3["NLRP3"] -->|"activates"| autism_spectrum_disorder["autism spectrum disorder"]
    style NLRP3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style autism_spectrum_disorder fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (12)

Target	Relation	Type	Str
oxidative stress response	involves	pathway	0.90
pyroptosis	involves	pathway	0.90
apoptosis pathway	involves	pathway	0.80
necroptosis	involves	pathway	0.70
PI3K-AKT-mTOR signaling	involves	pathway	0.70
mitochondrial function	involves	pathway	0.60
autophagy pathway	involves	pathway	0.60
JAK-STAT signaling	involves	pathway	0.60
ubiquitin-proteasome	involves	pathway	0.60
MAPK signaling	involves	pathway	0.60
ferroptosis	involves	pathway	0.60
NF-kB signaling	involves	pathway	0.60

Incoming (176)

Source	Relation	Type	Str
RLN1	associated_with	protein	0.90
GSDMD	interacts_with	gene	0.90
NLRP3	interacts_with	gene	0.90
Postsynaptic Interactomes	associated_with	pathway	0.90
SIRT1	protects_against	gene	0.85
decaBDE	causes	compound	0.85
Disease-Associated Microglia	associated_with	cell_type	0.85
BDE-209	causes	compound	0.85
HNRNP MUTATIONS	associated_with	gene	0.82
Tuberous Sclerosis Complex-Associated Epilepsy	associated_with	disease	0.82
ROS	activates	gene	0.80
GSDMD	activates	gene	0.80
NLRP3	activates	gene	0.80
ASC	interacts_with	gene	0.80
MICROBIOTA	implicated_in	biological_process	0.80
NLRP3	inhibits	gene	0.80
Microbiota-Gut-Brain Axis	associated_with	pathway	0.80
Melatonin	treats	drug	0.80
RhoA	associated_with	protein	0.75
Tuberous Sclerosis Complex	associated_with	disease	0.75
TLR4	activates	gene	0.70
rapamycin	treats	drug	0.70
PV	expressed_in	gene	0.70
perturbed ERK/MAPK signalling	associated_with	pathway	0.70
DNA	expressed_in	gene	0.60
MAPL	activates	gene	0.60
DNA	associated_with	gene	0.60
NLRP3	regulates	gene	0.60
GSDMD	inhibits	gene	0.60
PER1	associated_with	gene	0.60
PER2	associated_with	gene	0.60
GSDMD	regulates	gene	0.60
WNT	expressed_in	gene	0.60
GSDME	activates	gene	0.60
DNA	activates	gene	0.60
AIM2	activates	gene	0.60
BDNF	expressed_in	gene	0.60
RNA	regulates	gene	0.60
PVALB	associated_with	protein	0.60
ATP	interacts_with	gene	0.60
PER2	interacts_with	gene	0.60
DNA	regulates	gene	0.60
GSDMD	associated_with	gene	0.60
NPAS2	interacts_with	gene	0.60
MTNR1B	interacts_with	gene	0.60
PER1	interacts_with	gene	0.60
MTNR1A	interacts_with	gene	0.60
CLOCK	associated_with	gene	0.60
MTNR1B	associated_with	gene	0.60
PER3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.681

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This study reveals SYNGAP1 expression and function in radial glia before synapto

closed · Rounds: 4 · Score: 0.78 · 2026-04-16

Related Research

Hypotheses and analyses mentioning autism spectrum disorder in their description or question text

No additional research found