concept

PV

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

29Hypotheses

1Analyses

27Outgoing

24Incoming

2Experiments

1Debates

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💡 Concept Info

Name	PV
Key Genes/Proteins	ACC, ALS, AR, BIN1, CDK5, DRP1
Related Diseases	Alzheimer's disease, autism spectrum disorder, epilepsy
Linked Hypotheses	34 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PV[PV]
    PV -->|expressed in| Inhibitory_Neurons[Inhibitory Neurons]
    PV -->|promotes| motor_recovery[motor recovery]
    PV -->|expressed in| SST[SST]
    PV -->|expressed in| autism_spectrum_disorder[autism spectrum disorder]
    PV -->|phosphorylates| epilepsy[epilepsy]
    PNN[PNN] -->|activates| PV
    ACC[ACC] -->|regulates| PV
    HSPA1A[HSPA1A] -->|expressed in| PV
    CDK5[CDK5] -->|activates| PV
    DRP1[DRP1] -->|activates| PV
    JAK2[JAK2] -->|causes| PV
    NRG1[NRG1] -->|inhibits| PV

Outgoing (27)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PV	data_in	dataset_row	0.00
Inhibitory Neurons	expressed_in	cell_type	0.95
motor recovery	promotes	phenotype	0.95
autism spectrum disorder	expressed_in	disease	0.70
SST	regulates	gene	0.70
SST	inhibits	gene	0.70
SST	expressed_in	gene	0.70
Alzheimer's disease	interacts_with	disease	0.60
SST	activates	gene	0.60
SST	biomarker_for	gene	0.60
epilepsy	interacts_with	disease	0.60
epilepsy	activates	disease	0.60
schizophrenia	associated_with	disease	0.60
epilepsy	inhibits	disease	0.60
epilepsy	associated_with	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
autism spectrum disorder	implicated_in	disease	0.60
autism spectrum disorder	inhibits	disease	0.60
Alzheimer's disease	inhibits	disease	0.60
Alzheimer's disease	causes	disease	0.60
epilepsy	phosphorylates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
SST	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (24)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PV	data_in	dataset_row	0.00
PNN	activates	gene	0.80
ACC	regulates	gene	0.70
ACC	expressed_in	gene	0.60
PNN	expressed_in	gene	0.60
PNN	translocates_to	gene	0.60
PNN	inhibits	gene	0.60
CDK5	activates	gene	0.60
DRP1	activates	gene	0.60
CDK5	phosphorylates	gene	0.60
JAK2	causes	gene	0.60
JAK2	interacts_with	gene	0.60
JAK2	associated_with	gene	0.60
JAK2	activates	gene	0.60
NRG1	associated_with	gene	0.60
NRG1	inhibits	gene	0.60
AR	associated_with	gene	0.60
NMDAR	expressed_in	gene	0.60
ALS	co_expressed_with	gene	0.60
GABA	inhibits	gene	0.60
HSPA1A	expressed_in	gene	0.60
GDNF	associated_with	gene	0.60
BIN1	causes	gene	0.60
BIN1	associated_with	gene	0.60

Targeting Hypotheses (29)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop optogenetic targeting PV interneurons to restore	0.944	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.867	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.858	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.857	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.843	molecular neurobiology	View
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.785	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.743	neurodegeneration	What are the physiological functions of
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d
Ketone-Based Metabolic Switching to Restore PV Interneuron F	0.609	neurodegeneration	test
Closed-loop transcranial focused ultrasound with real-time g	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
Real-time closed-loop transcranial focused ultrasound target	0.559	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.542	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma-Entrained PV Interneurons Enable p-tau217-Guided Preci	0.536	molecular neurobiology	View
Gamma-Entrained PV Interneuron Networks Enable Precision p-t	0.536	molecular neurobiology	View
Gamma-Entrained PV Interneurons Enable Precision p-tau217-Gu	0.461	molecular neurobiology	View
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (1)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning PV in their description or question text

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.858 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Score: 0.857 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagat

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

Score: 0.846 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening to restore hippo

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.843 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.827 · Alzheimer's disease · 2026-04-16

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Score: 0.827 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Score: 0.797 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f

Closed-loop transcranial alternating current stimulation to restore hippocampal-

Score: 0.785 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma

Prefrontal sensory gating circuit restoration via PV interneuron enhancement

Score: 0.775 · Alzheimer's disease · 2026-04-02

## Molecular Mechanism and Rationale Parvalbumin-expressing (PV+) interneurons represent the most abundant class of GAB

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli

Score: 0.747 · neurodegeneration · 2026-04-15

**Molecular Mechanism and Rationale** The complement system's classical pathway, initiated by C1q complex formation, re

BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Intern

Score: 0.743 · neurodegeneration · 2026-04-15

## Mechanistic Overview BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Interneuron Hypofuncti

Complement C1QA Inhibition Synergizes with PV Interneuron Modulation

Score: 0.659 · neurodegeneration · 2026-04-13

## Mechanistic Overview Complement C1QA Inhibition Synergizes with PV Interneuron Modulation starts from the claim that

Ketone-Based Metabolic Switching to Restore PV Interneuron Function

Score: 0.609 · neurodegeneration · 2026-04-16

## Mechanistic Overview Ketone-Based Metabolic Switching to Restore PV Interneuron Function starts from the claim that m

Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

Score: 0.564 · Alzheimer's disease · 2026-04-17

## Mechanistic Overview Closed-loop transcranial focused ultrasound with real-time gamma feedback to restore PV interneu

Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons

Score: 0.564 · Alzheimer's disease · 2026-04-20

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore Anky

PV

Understanding Entity Pages

Wiki Pages (20)

Paraventricular Hypothalamic Nucleus (PVN) Neurons

PVALB Gene - Parvalbumin

MPV17 Gene - MPV17 Mitochondrial Inner Membrane Protein

TRPV5

TRPV2 — Transient Receptor Potential Cation Channel Subfamily V Member 2

TRPV6

PV Interneurons (Hippocampus)

Parvalbumin-Positive (PV+) Interneurons

TRPV1 Sensory Neurons

Periventricular Nucleus (PVN) Neurons

Cortical PV Fast-Spiking Interneurons

TRPV2 Protein

Parvalbumin (PV) Neurons

TRPV4 Gene

TRPV4 Protein

TRPV1 Protein

Parvalbumin-Positive (PV+) Interneurons

MPV17 Protein

Paraventricular Nucleus (PVN) Neurons

Parvalbumin Neurons (PV+)

Pathway Diagram

Outgoing (27)

Incoming (24)

Targeting Hypotheses (29)

Mentioning Analyses (1)

Are interneuron oscillation deficits compensatory responses or primary pathologi

Experiments (2)

Related Papers (0)

Debates (1)

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

Related Research

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling f

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop transcranial alternating current stimulation to restore hippocampal-

Prefrontal sensory gating circuit restoration via PV interneuron enhancement

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli

BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Intern

Complement C1QA Inhibition Synergizes with PV Interneuron Modulation

Ketone-Based Metabolic Switching to Restore PV Interneuron Function

Closed-loop transcranial focused ultrasound with real-time gamma feedback to res

Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons