process

Microbiota

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Microbiota: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

658Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

3Experiments

2Debates

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🧬 Biological Process Info

Name	Microbiota
Key Genes/Proteins	AGING, AHR, AKT, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALS
Related Diseases	aging, Aging, Als, Alzheimer, Alzheimer Disease
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Gut Microbiota Dysbiosis

phenotype · 707 words

→

Pathway Diagram

graph TD
    Microbiota["Microbiota"]
    Gut_Brain_Axis["Gut-Brain Axis"]
    Microbiota -->|"regulates"| Gut_Brain_Axis
    Immune_System["Immune System"]
    Microbiota -->|"interacts_with"| Immune_System
    Vagus_Nerve["Vagus Nerve"]
    Microbiota -->|"interacts_with"| Vagus_Nerve
    Enteric_Nervous_System["Enteric Nervous System"]
    Microbiota -->|"interacts_with"| Enteric_Nervous_System
    Microglia["Microglia"]
    Microbiota -->|"activates"| Microglia
    Als{"Als"}
    Als -->|"activates"| Microbiota
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"activates"| Microbiota
    Inflammation{"Inflammation"}
    Inflammation -->|"activates"| Microbiota
    style Microbiota fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Gut-Brain Axis	regulates	pathway	0.95
Gut-Brain Axis	component_of	pathway	0.95
Glaucoma	contributes_to	disease	0.95
central nervous system	communicates_with	organ	0.90
Butyrate	associated_with	compound	0.90
Immune System	interacts_with	pathway	0.90
Vagus Nerve	interacts_with	pathway	0.90
Enteric Nervous System	interacts_with	pathway	0.90
Microglia	activates	cell_type	0.85
WILSON-KONOVALOV DISEASE	implicated_in	disease	0.80
MULTISYSTEM ATROPHY	implicated_in	disease	0.80
HUNTINGTON'S CHOREA	implicated_in	disease	0.80
TEMPORAL LOBE EPILEPSY	implicated_in	disease	0.80
Autism	associated_with	disease	0.80
Anxiety	associated_with	disease	0.80
Schizophrenia	associated_with	disease	0.80
Parkinson's Disease	associated_with	disease	0.80
Alzheimer's Disease	associated_with	disease	0.80
Obesity	associated_with	disease	0.80
ENTERIC NERVOUS SYSTEM	interacts_with	biological_process	0.80
AUTISM SPECTRUM DISORDER	implicated_in	disease	0.80
RETT SYNDROME	implicated_in	disease	0.80
ATTENTION DEFICIT HYPERACTIVITY DISORDER	implicated_in	disease	0.80
NON-ALZHEIMER'S NEURODEGENERATION AND DEMENTIAS	implicated_in	disease	0.80
FRONTO-TEMPORAL LOBE DEMENTIA	implicated_in	disease	0.80
PARKINSON'S DISEASE	implicated_in	disease	0.80
MULTIPLE SCLEROSIS	implicated_in	disease	0.80
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	disease	0.80
SCHIZOPHRENIA	implicated_in	disease	0.80
ALZHEIMER'S DISEASE	implicated_in	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
DEPRESSION	implicated_in	disease	0.80
SOCIAL_BEHAVIOUR	regulates	phenotype	0.64
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
Pain	regulates	disease	0.50
Dysbiosis	regulates	disease	0.50
Dysbiosis	expressed_in	disease	0.50
Sarcopenia	associated_with	disease	0.50
Gastric Cancer	associated_with	disease	0.50
Gut Microbiota	expressed_in	process	0.50
GENE EXPRESSION	expressed_in	concept	0.50
STEM CELLS	associated_with	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
Inflammatory Bowel Disease	causes	disease	0.50
NAFLD	regulates	disease	0.50
DOPAMINE	inhibits	concept	0.50
DOPAMINERGIC NEURONS	inhibits	concept	0.50
Liver Cancer	interacts_with	disease	0.50
α-SYNUCLEIN	activates	concept	0.50

Incoming (572)

Source	Relation	Type	Str
INFLAMMATION	regulates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	associated_with	disease	1.00
Als	activates	disease	1.00
Als	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	regulates	disease	1.00
ALZHEIMER	regulates	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	regulates	disease	1.00
Alzheimer	regulates	disease	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
NEUROINFLAMMATION	regulates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Neuroinflammation	regulates	disease	1.00
GENES	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
MICROGLIA	activates	gene	1.00
Aging	regulates	disease	0.90
TNF-Α	activates	gene	0.90
TNF	activates	gene	0.90
INFLAMMATION	inhibits	gene	0.90
Inflammation	inhibits	disease	0.90
OXIDATIVE STRESS	therapeutic_target	gene	0.90
NF-ΚB	inhibits	gene	0.90
AUTOPHAGY	regulates	gene	0.90
Als	treats	disease	0.90
GUT-BRAIN AXIS	activates	gene	0.90
Inflammatory Bowel Disease	activates	disease	0.90
CANCER	activates	gene	0.90
Cancer	activates	disease	0.90
IL-6	activates	gene	0.90
Obesity	activates	disease	0.90
AMYLOID	activates	gene	0.80
ALZHEIMER	associated_with	gene	0.80
DEPRESSION	activates	gene	0.80
NEUROINFLAMMATION	associated_with	gene	0.80
Neurodegeneration	activates	disease	0.80
Depression	activates	disease	0.80
NEURODEGENERATION	activates	gene	0.80
Neuroinflammation	associated_with	disease	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80
ROS	regulates	gene	0.80
INSULIN RESISTANCE	regulates	gene	0.80
Inflammatory Bowel Disease	therapeutic_target	disease	0.80
CYTOKINES	inhibits	gene	0.80
Insulin Resistance	regulates	disease	0.80
AGING	regulates	gene	0.80
Inflammatory Bowel Disease	regulates	disease	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microbiota-Microglia Axis Modulation	0.651	neurodegeneration	Neuroinflammation and microglial priming
Fecal Microbiota Transplantation to Reset Microglial Priming	0.440	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Single-cell RNA sequencing of EMT states in SCC	exploratory	Skin squamous cell carcinoma	0.900	Primary mouse model	proposed	N/A
Gene expression analysis of autophagy targets following trehalose trea	exploratory	motoneuron degeneration	0.850	neuronal cell lines	proposed	N/A
Trehalose-induced autophagy gene expression analysis	exploratory	motoneuron degeneration	0.850	NSC34 neuroblastoma x spinal c	proposed	N/A

Related Papers (13)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Biochemistry, Histamine. [PMID:32491722]	Patel, Rahimi		2026
Ferroptosis and Cuproptosis in Cancer and Neurodegeneration: A Comprehensive Rev [PMID:41897286]	["Tolbatov Iogann", "Marrone Alessandro"	Biomolecules	2026
Cell death in multiple sclerosis. [PMID:40926029]	Guan S, Zhu H, Zhang M, Shi FD, Yan B	Cell death and differentiation	2026
Astrocytic mGluR5-dependent calcium hyperactivity promotes amyloid-β pathology a [PMID:40377015]	Yang T, Zhang D, Huang H, Liu F, Wu J et	Brain	2026
Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850]	Saadmaan G, Dalmasso MC, Maria M, Lehtis	Brain	2026
OMG! A proteomic determinant of neurodegenerative resiliency. [PMID:41491993]	Duggan MR, Oh HS, Frank P, Gomez GT, Zwe	Mol Neurodegener	2026
Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: [PMID:41683467]	Czaj PV, Szewczyk-Golec K, Nuszkiewicz J	Molecules	2026
Bile acid-microbiota interactions in multiple sclerosis: From experimental model [PMID:41806463]	Atasever Ü	J Neuroimmunol	2026
The IL-23/IL-17 axis in Behçet's syndrome pathogenesis: from immunological persp [PMID:41884836]	Naffaa ME, Hassan F, Omar M, Abacar K, M	Front Immunol	2026
Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportuni [PMID:41906403]	Correale J	J Neurochem	2026
Neurodegeneration and Homelessness: A Bidirectional Relationship Shaping Health [PMID:41918504]	Stouffer ACF, Kumar SL	Yale J Biol Med	2026
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis. [PMID:41349546]	Lorenz SM, Wahida A, Bostock MJ, Seibt T	Cell	2026
Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis. [PMID:41661214]	["Miller Timothy M", "Cudkowicz Merit E"	JAMA neurology	2026

Debates (2)

Multi-agent debates referencing this entity

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 4 · Score: 0.86 · 2026-04-12

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 5 · Score: 0.95 · 2026-04-12

Related Research

Hypotheses and analyses mentioning Microbiota in their description or question text

No additional research found