gene

SYNGAP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNGAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

1Hypotheses

1Analyses

11Outgoing

7Incoming

0Experiments

2Debates

Summary

Page for SYNGAP1 — Synaptic Ras GTPase Activating Protein 1

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🧬 Gene Info

Gene Symbol	SYNGAP1
Full Name	Synaptic Ras GTPase Activating Protein 1
Chromosome	6p21.3
Function	is a major postsynaptic density (PSD) protein that regulates Ras signaling and controls AMPA receptor trafficking, making it essential for synaptic plasticity, learning, and memory.
Primary Expression	Brain (cortex, hippocampus), postsynaptic densities
Molecular Weight	150 kDa
Amino Acids	1343 aa
UniProt ID	[Q9ULB0](https://www.uniprot.org/uniprot/Q9ULB0)
Ensembl ID	ENSG00000197283
OMIM	603384
GeneCards	SYNGAP1
Human Protein Atlas	SYNGAP1
N-terminal domain	Contains a C2 domain (Ca²⁺/lipid-binding)
PDZ-binding motif	Mediates interaction with PSD-95 and other scaffolding proteins
SH3 domain	Protein-protein interactions
Associated Diseases	neurodegeneration
Interactions	ERK, RAS, STXBP1
SciDEX Hypotheses	Interneuron SYNGAP1 Deficiency Disrupts Cortical C
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SYNGAP1 — Synaptic Ras GTPase Activating Protein 1

gene · 1297 words

→

SYNGAP1-Related Epilepsy

disease · 1335 words

→

Pathway Diagram

graph TD
    SYNGAP1["SYNGAP1"]
    Aging{"Aging"}
    SYNGAP1 -->|"therapeutic target"| Aging
    Als{"Als"}
    SYNGAP1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    SYNGAP1 -->|"therapeutic target"| Ms
    ERK["ERK"]
    SYNGAP1 -->|"inhibits"| ERK
    Epigenetic(["Epigenetic"])
    SYNGAP1 -->|"therapeutic target"| Epigenetic
    neurodegeneration["neurodegeneration"]
    SYNGAP1 -->|"implicated in"| neurodegeneration
    SCN1A["SCN1A"]
    SCN1A -->|"therapeutic target"| SYNGAP1
    STXBP1["STXBP1"]
    STXBP1 -->|"inhibits"| SYNGAP1
    ERK -->|"inhibits"| SYNGAP1
    RAS["RAS"]
    RAS -->|"inhibits"| SYNGAP1
    AND["AND"]
    AND -->|"inhibits"| SYNGAP1
    style SYNGAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ERK	inhibits	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
autism spectrum disorder	activates	disease	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
stem cells	expressed_in	cell_type	0.60
Chaperone	inhibits	pathway	0.60
neurodevelopment	promoted: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Development	disease	0.58

Incoming (7)

Source	Relation	Type	Str
SCN1A	therapeutic_target	gene	0.60
STXBP1	inhibits	gene	0.60
neurogenesis	binds_to	process	0.60
ERK	inhibits	gene	0.60
RAS	inhibits	gene	0.60
DYRK1A	targets	gene	0.60
SCN2A	targets	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.683	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.683

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Debate: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

This study reveals SYNGAP1 expression and function in radial glia before synapto

closed · Rounds: 4 · Score: 0.78 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SYNGAP1 in their description or question text

No additional research found