Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about F3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | F3 |
| Key Genes/Proteins | ADORA2B, ALOX12, BDNF, BECN1, ELAVL1, GFAP |
| Related Diseases | autism spectrum disorder, glioblastoma |
| Related Pathways | autophagy pathway, ferroptosis |
Knowledge base pages for this entity
graph TD
F3[F3]
F3 -->|involved_in| Coagulation[Coagulation]
F3 -->|participates in| ferroptosis[ferroptosis]
F3 -.biomarker for.-> GFAP[GFAP]
F3 -.biomarker for.-> MBP[MBP]
F3 -->|activates| P2RX1[P2RX1]
F3 -->|activates| P2RX4[P2RX4]
F3 -->|activates| P2RX5[P2RX5]
F3 -->|activates| P2RX7[P2RX7]
F3 -->|activates| P2RY1[P2RY1]
F3 -->|activates| P2RY12[P2RY12]
IFNB[IFNB] -->|upregulates| F3
Gsdmd_Dependent_Pyroptosis[Gsdmd-Dependent Pyroptosis] -->|involved_in| F3
BECN1[BECN1] -->|activates| F3
ELAVL1[ELAVL1] -->|activates| F3
BDNF[BDNF] -->|activates| F3
ADORA2B[ADORA2B] -->|activates| F3
ALOX12[ALOX12] -->|activates| F3
benchmark_ot_ad_answer_key_F3[benchmark_ot_ad_answer_key:F3] -->|data_in| F3| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:F3 | data_in | dataset_row | 0.00 |
| Coagulation | involved_in | process | 0.80 |
| IFN | activates | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| autism spectrum disorder | inhibits | disease | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| MBP | biomarker_for | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| P2RX4 | activates | gene | 0.60 |
| P2RX5 | activates | gene | 0.60 |
| P2RX7 | activates | gene | 0.60 |
| P2RY1 | activates | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| PANX1 | activates | gene | 0.60 |
| GSDMD | inhibits | gene | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| glioblastoma | biomarker_for | disease | 0.60 |
| P2RX1 | activates | gene | 0.60 |
| stem cells | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:F3 | data_in | dataset_row | 0.00 |
| IFNB | upregulates | gene | 0.85 |
| Gsdmd-Dependent Pyroptosis | involved_in | process | 0.85 |
| BDNF | activates | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| BDNF | biomarker_for | gene | 0.60 |
| ADORA2B | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| ALOX12 | inhibits | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ELAVL1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.624
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning F3 in their description or question text
No additional research found