concept

MICROBIOTA-GUT-BRAIN AXIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROBIOTA-GUT-BRAIN AXIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

28Outgoing

19Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	MICROBIOTA-GUT-BRAIN AXIS

Pathway Diagram

graph TD
    MICROBIOTA_GUT_BRAIN_AXIS["MICROBIOTA-GUT-BRAIN AXIS"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"interacts"| Central_Nervous_System["Central Nervous System"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"interacts"| Enteric_Nervous_System["Enteric Nervous System"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"involved_in"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"mediates"| Parkinson_s_Disease_Progressio["Parkinson's Disease Progression"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"regulates"| Neurodevelopment["Neurodevelopment"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"regulates"| Host_Behavior["Host Behavior"]
    MICROBIOTA_GUT_BRAIN_AXIS -->|"involved_in"| Parkinson_S_Disease["Parkinson'S Disease"]
    Immune_System["Immune System"] -->|"mediates"| MICROBIOTA_GUT_BRAIN_AXIS
    Tryptophan_Metabolism["Tryptophan Metabolism"] -->|"mediates"| MICROBIOTA_GUT_BRAIN_AXIS
    Vagus_Nerve["Vagus Nerve"] -->|"mediates"| MICROBIOTA_GUT_BRAIN_AXIS
    Stress["Stress"] -->|"modulates"| MICROBIOTA_GUT_BRAIN_AXIS
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"modulates"| MICROBIOTA_GUT_BRAIN_AXIS
    Enteric_Glia["Enteric Glia"] -->|"component_of"| MICROBIOTA_GUT_BRAIN_AXIS

Outgoing (28)

Target	Relation	Type	Str
Enteric Nervous System	interacts_with	cell_type	0.95
Central Nervous System	interacts_with	cell_type	0.95
Alzheimer'S Disease	involved_in	disease	0.93
Parkinson's Disease	involved_in	disease	0.92
Microglial Activation	modulates	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.90
PARKINSON'S DISEASE	associated_with	disease	0.90
ALS	associated_with	disease	0.90
DEMENTIA	associated_with	disease	0.90
NEURODEGENERATION	involved_in	process	0.90
Multiple Sclerosis	associated_with	disease	0.90
Parkinson's Disease Progression	mediates	process	0.90
Neurodevelopment	regulates	process	0.90
Host Behavior	regulates	phenotype	0.90
neurological diseases	implicated_in	disease	0.90
Parkinson's Disease Progression	regulates	process	0.87
Alzheimer's Disease	involved_in	disease	0.85
Immune Pathway	involved_in	pathway	0.85
Autism Spectrum Disorder	associated_with	disease	0.80
Parkinson's disease	associated_with	disease	0.80
Depression	involved_in	disease	0.80
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
NEUROINFLAMMATION	regulates	process	0.75
Schizophrenia	associated_with	disease	0.75
depression	regulates	disease	0.72
neuroinflammation	regulates	process	0.70

Incoming (19)

Source	Relation	Type	Str
Vagus Nerve	mediates	cell_type	0.90
Tryptophan Metabolism	mediates	pathway	0.90
Immune System	mediates	process	0.90
Stress	modulates	phenotype	0.90
Endocrine Pathway	component_of	pathway	0.85
Immune Pathway	component_of	pathway	0.85
Short-Chain Fatty Acids	modulates	compound	0.85
Tryptophan Metabolism	involved_in	pathway	0.85
Short-Chain Fatty Acids	mediates	compound	0.85
Enteric Glia	component_of	cell_type	0.85
Neurologic Drugs	modulates	drug	0.80
bile acids	interacts_with	compound	0.80
Exercise	modulates	process	0.75
neural pathway	upstream_of	pathway	0.70
immune pathway	upstream_of	pathway	0.70
small-molecule compounds	regulates	drug	0.70
stress	modulates	phenotype	0.68
psychotropic agents	modulates	drug	0.65
exercise	modulates	phenotype	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MICROBIOTA-GUT-BRAIN AXIS in their description or question text

No additional research found