gene

CIC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

41Outgoing

20Incoming

0Experiments

0Debates

Summary

CIC (Capicua) is an HMG-box transcriptional repressor involved in neuronal gene regulation, brain development, and disease. Associated with SCA1, SCA2, ataxia, and neurodevelopmental disorders.

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🧬 Gene Info

Gene Symbol	CIC
Full Name	Capicua Transcriptional Repressor
Aliases	Capicua
Chromosome	19p13.2
Protein Family	Capicua family (HMG-box transcriptional repressor)
Function	is an HMG-box family transcriptional repressor that plays critical roles in neuronal development, brain patterning, and synaptic plasticity.
Amino Acids	608 aa
Pathways	Alpha-Synuclein
UniProt ID	Q96PY5
NCBI Gene ID	2055
Ensembl ID	ENSG00000105143
OMIM	607400
GeneCards	CIC
Human Protein Atlas	CIC
Associated Diseases	AD, autism spectrum disorder, cancer, glioma, Ms, pilocytic astrocytoma
Interactions	ALPHA-SYNUCLEIN, ATXN1, PARKINSON, PARKINSON'S DISEASE
KG Connections	61 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CIC — AlphaFold Q96PY5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CIC - Capicua Transcriptional Repressor

gene · 1609 words

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Pathway Diagram

graph TD
    CIC["CIC"]
    Cancer{"Cancer"}
    CIC -->|"biomarker for"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    CIC -->|"biomarker for"| Neurodegeneration
    Ms{"Ms"}
    CIC -->|"biomarker for"| Ms
    Glioma{"Glioma"}
    CIC -->|"biomarker for"| Glioma
    Parkinson{"Parkinson"}
    CIC -->|"activates"| Parkinson
    FUBP1["FUBP1"]
    CIC -->|"associated with"| FUBP1
    H3F3A["H3F3A"]
    CIC -->|"associated with"| H3F3A
    OVERVIEW["OVERVIEW"]
    CIC -->|"biomarker for"| OVERVIEW
    BRAF["BRAF"]
    CIC -->|"associated with"| BRAF
    ATRX["ATRX"]
    CIC -->|"associated with"| ATRX
    IDH1["IDH1"]
    CIC -->|"associated with"| IDH1
    JUN["JUN"]
    CIC -->|"biomarker for"| JUN
    IDH1 -->|"associated with"| CIC
    TERT["TERT"]
    TERT -->|"associated with"| CIC
    JUN -->|"biomarker for"| CIC
    BRAF -->|"associated with"| CIC
    FUBP1 -->|"associated with"| CIC
    H3F3A -->|"associated with"| CIC
    ATRX -->|"associated with"| CIC
    OVERVIEW -->|"biomarker for"| CIC
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| CIC
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| CIC
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"activates"| CIC
    AND["AND"]
    AND -->|"associated with"| CIC
    style CIC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
BRAIN TUMOURS	associated_with	entity	0.85
neurons	expressed_in	cell_type	0.70
Parkinson	activates	disease	0.65
Cancer	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Glioma	biomarker_for	disease	0.65
App	biomarker_for	protein	0.60
Fus	associated_with	protein	0.60
Raf	associated_with	protein	0.60
Alpha-Synuclein	activates	pathway	0.60
stem cells	expressed_in	cell_type	0.60
autism spectrum disorder	associated_with	disease	0.60
FUBP1	biomarker_for	gene	0.60
H3F3A	biomarker_for	gene	0.60
IDH1	biomarker_for	gene	0.60
TERT	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
PARKINSON	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
FUBP1	associated_with	gene	0.60
H3F3A	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
BRAF	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
TERT	associated_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
IDH1	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
ATRX	biomarker_for	gene	0.60
T Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
RA	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
AD	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
cancer	implicated_in	disease	0.50
glioma	implicated_in	disease	0.50
pilocytic astrocytoma	implicated_in	disease	0.50

Incoming (20)

Source	Relation	Type	Str
ATXN1	interacts_with	gene	0.80
IDH1	associated_with	gene	0.60
TERT	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
ATXN1	causes	gene	0.60
ATRX	biomarker_for	gene	0.60
ATRX	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
CANCER	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
BRAF	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
H3F3A	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
TERT	biomarker_for	gene	0.60
FUBP1	biomarker_for	gene	0.60
H3F3A	biomarker_for	gene	0.60
BRAF	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CIC in their description or question text

No additional research found