Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHD1 |
| Full Name | Chromodomain Helicase DNA Binding Protein 1 |
| Chromosome | 5q21.1 |
| Protein Type | ATP-dependent chromatin remodeler |
| Function | is a member of the chromodomain helicase/ATPase (CHD) family of proteins that utilize ATP to remodel chromatin structure [@chd]. |
| Molecular Weight | 223 kDa |
| Amino Acids | 300 aa |
| Pathways | Cholesterol, lipid metabolism |
| UniProt ID | Q86W28 |
| NCBI Gene ID | 1105 |
| Ensembl ID | ENSG00000153922 |
| OMIM | 602118 |
| GeneCards | CHD1 |
| Human Protein Atlas | CHD1 |
| Associated Diseases | Aging, ALS, Cancer, disease, TUMOR |
| Interactions | AR, CANCER, SPOP |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHD1["CHD1"]
Cancer{"Cancer"}
CHD1 -->|"therapeutic_target"| Cancer
Aging{"Aging"}
CHD1 -->|"associated_with"| Aging
Als{"Als"}
CHD1 -->|"therapeutic_target"| Als
Tumor{"Tumor"}
CHD1 -->|"activates"| Tumor
ALS{"ALS"}
CHD1 -->|"causes"| ALS
SREBP2(["SREBP2"])
SREBP2 -->|"causes"| CHD1
SPOP(["SPOP"])
SPOP -->|"therapeutic_target"| CHD1
CANCER(["CANCER"])
CANCER -->|"activates"| CHD1
style CHD1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Aging | encodes | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Rb | therapeutic_target | protein | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| SREBP2 | causes | gene | 0.60 |
| CANCER | causes | gene | 0.60 |
| SPOP | therapeutic_target | gene | 0.60 |
| Lipid Metabolism | encodes | pathway | 0.60 |
| SPOP | interacts_with | gene | 0.60 |
| SPOP | associated_with | gene | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| SPOP | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| TUMOR | causes | disease | 0.50 |
| Cholesterol | causes | pathway | 0.50 |
| TUMOR | interacts_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| LIPID METABOLISM | associated_with | pathway | 0.50 |
| SREBP2 | associated_with | concept | 0.50 |
| TUMOR | activates | disease | 0.50 |
| Cholesterol | associated_with | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CHD1 in their description or question text
No additional research found