gene 2,535 words KG: ARNTL
Contents

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

🧬 Gene Info
Gene SymbolARNTL
Full NameAryl Hydrocarbon Receptor Nuclear Translocator Like
AliasesBMAL1, MOP3
Chromosome11p15.3
Protein TypeTranscription Factor
FunctionCore circadian clock transcription factor
Primary ExpressionUbiquitous, highest in SCN, cortex, hippocampus
Molecular Weight68.9 kDa
Amino Acids626
PathwaysCircadian rhythm, CLOCK-BMAL1 pathway
UniProt IDO00327
NCBI Gene ID105
Ensembl IDENSG00000133794
OMIM602550
GeneCardsARNTL
Human Protein AtlasARNTL
Associated DiseasesAging, ALS, autism spectrum disorder, Carcinoma, Diabetes, Ferroptosis
InteractionsAGING, ALOX, AND, ATG, BMAL1, CANCER
SciDEX HypothesesBMAL1-CLOCK regulation of miR-143/145 locks microg
KG Connections186 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (21)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84

Related Analyses (10)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (3)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ATM Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits

Knowledge Graph (12 edges)

BMAL1 regulates ARNTL
CLOCK regulates ARNTL
MAP1LC3B associated_with ARNTL
GPX4 associated_with ARNTL
BMAL1 associated_with ARNTL
LC3 associated_with ARNTL
NCOA4 associated_with ARNTL
ARNTL associated_with CGAS
ARNTL associated_with SLC7A11
ARNTL associated_with TMEM173

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