| Gene Symbol | AR |
| Chromosome | Xq12 |
| Protein Type | Gene |
| Function | encodes a nuclear receptor protein that binds testosterone and dihydrotestosterone, mediating the effects of androgen hormones in target tissues. |
| Primary Expression | brain regions including: - Spinal cord: Motor neurons, including those innervating skeletal muscle - Hypothalamus: Regulatory centers for hor |
| Molecular Weight | 110 kDa |
| Amino Acids | 919 aa |
| GeneCards | AR |
| Human Protein Atlas | AR |
| N-terminal domain (NTD) | Contains the AF-1 activation function and polyQ tract |
| DNA-binding domain (DBD) | Two zinc finger motifs for GRE binding |
| Hinge region | Contains the nuclear localization signal |
| Ligand-binding domain (LBD) | Binds testosterone/DHT; contains AF-2 |
| Spinal cord | Motor neurons, including those innervating skeletal muscle |
| Hypothalamus | Regulatory centers for hormone release |
| Associated Diseases | Aromatase Inhibitor Resistance, cancer |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, AKT, ALS, AMBRA1, AMPK, APP |
| SciDEX Hypotheses | Testosterone-Derived DHT Amplifies Microglial Andr |
| KG Connections | 178 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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