protein 2,779 words KG: FBXO7
Contents

FBXO7 Protein (PARK15)

🔬 Protein Info
Gene SymbolFBXO7
Full NameF-box Only Protein 7
AliasesPARK15
Chromosome22q12
Functionis a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex.
Molecular Weight57 kDa
Amino Acids524 aa
PathwaysmTOR, NF-κB, Wnt
GeneCardsFBXO7
Human Protein AtlasFBXO7
Associated DiseasesAls, Alzheimer, Cardiomyopathy, Cardiovascular, DOPAMINE
InteractionsAKT, ATP13A2, CHCHD2, CLPP, DJ1, DNAJC6
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

APOE-Dependent Autophagy Restoration
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: associated_with
ATP1A3 Gene - Sodium-Potassium ATPase Alpha 3
gene · KG edge: associated_with
BCS1L Gene
gene · KG edge: associated_with
CD14 — CD14 Molecule
gene · KG edge: associated_with
DNAJC13 — DnaJ Heat Shock Protein Family Member C13
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TP53 causes FBXO7
FBXO7 activates MDM2
FBXO7 activates RPL23
TIMMDC1 associated_with FBXO7
CD14 therapeutic_target FBXO7
FBXO7 associated_with LYRM7
FBXO7 associated_with BCS1L
FBXO7 biomarker_for Septic Cardiomyopathy
GCH1 associated_with FBXO7
VPS35 associated_with FBXO7

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