concept

SPOP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPOP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

50Outgoing

10Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SPOP
Key Genes/Proteins	AND, ANTIOXIDANT GENES, AR, AUTOPHAGY, BRD4, CANCER
Related Diseases	Aging, Als, ALS, cancer, Cancer
Related Pathways	Autophagy

Pathway Diagram

graph TD
    SPOP["SPOP"]
    SPOP -->|"regulates"| SQSTM1["SQSTM1"]
    SPOP -->|"contributes to"| Ms["Ms"]
    SPOP -->|"activates"| Als["Als"]
    SPOP -->|"contributes to"| Tumor["Tumor"]
    SPOP -->|"activates"| Cancer["Cancer"]
    SPOP -->|"target for"| Aging["Aging"]
    SREBP2["SREBP2"] -->|"causes"| SPOP
    CHD1["CHD1"] -->|"target for"| SPOP

Outgoing (54)

Target	Relation	Type	Str
ubiquitin-proteasome pathway	involved_in	pathway	0.95
CUL3	interacts_with	protein	0.95
Proteasomal Degradation	mediates	process	0.95
Cullin 3	interacts_with	protein	0.95
Ubiquitination	mediates	process	0.95
Tumor Suppressor	associated_with	mechanism	0.95
AR	degrades	protein	0.90
proteolytic degradation	mediates	process	0.90
Prostate Cancer	suppresses	disease	0.90
BRD4	degrades	protein	0.85
CD274	degrades	protein	0.85
ERG	degrades	protein	0.85
MYC	degrades	protein	0.85
CDC20	degrades	protein	0.85
SRC3	degrades	protein	0.85
Prostate Cancer	therapeutic_target	disease	0.85
SQSTM1	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.70
Cancer	activates	disease	0.65
Tumor	contributes_to	disease	0.65
Als	activates	disease	0.65
Ms	contributes_to	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
Tumor	activates	disease	0.65
Cancer	causes	disease	0.65
Aging	causes	disease	0.65
Rb	therapeutic_target	protein	0.60
CHD1	activates	gene	0.60
cancer	inhibits	disease	0.60
SREBP2	causes	gene	0.60
CANCER	causes	gene	0.60
Lipid Metabolism	causes	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
SRC3	inhibits	gene	0.60
CHD1	therapeutic_target	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Cholesterol	activates	pathway	0.60
SQSTM1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
KEAP1	regulates	gene	0.60
CANCER	activates	gene	0.60
P62	activates	gene	0.60
Autophagy	activates	pathway	0.60

Incoming (10)

Source	Relation	Type	Str
CHD1	therapeutic_target	gene	0.60
PTEN	inhibits	gene	0.60
AR	inhibits	gene	0.60
BRD4	inhibits	gene	0.60
MYC	inhibits	gene	0.60
CHD1	interacts_with	gene	0.60
CHD1	associated_with	gene	0.60
AR	activates	gene	0.60
CHD1	activates	gene	0.60
SREBP2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPOP in their description or question text

No additional research found