Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GABRA6 |
| Full Name | Gamma-Aminobutyric Acid Type A Receptor Alpha 6 Subunit |
| Chromosome | 5q34 |
| Protein Type | Receptor |
| Function | encodes a protein that assembles with other GABA-A receptor subunits to form functional chloride channels. |
| Primary Expression | cerebellar granule cells, making it one of the most cell-type-specific GABA-A receptor subunits in the brain |
| Molecular Weight | 51 kDa |
| Amino Acids | 456 aa |
| UniProt ID | P47870 |
| NCBI Gene ID | 2565 |
| Ensembl ID | ENSG00000145945 |
| OMIM | 137143 |
| GeneCards | GABRA6 |
| Human Protein Atlas | GABRA6 |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["GABRA6"]
N1["AR"]
N1 -->|"regulates"| N0
N2["PIK3CG"]
N0 -->|"regulates"| N2
N3["PPARG"]
N0 -->|"regulates"| N3
N4["TNF"]
N0 -->|"regulates"| N4
N5["neurodegeneration"]
N0 -->|"implicated in"| N5
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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class N0 gene
class N1 gene
class N2 gene
class N3 gene
class N4 gene| Source | Relation | Type | Str |
|---|---|---|---|
| AR | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GABRA6 in their description or question text
No additional research found