| Gene Symbol | TIGAR |
| Full Name | TP53-Induced Glycolysis and Apoptosis Regulator |
| Chromosome | 12p13.1 |
| Protein Type | Enzyme |
| Function | is a gene encoding a bifunctional enzyme with fructose-2,6-bisphosphatase activity. |
| Exons | 6 |
| Pathways | Apoptosis, Autophagy, Chaperone, Glycolysis, Mitophagy |
| UniProt ID | [Q9Y2H7](https://www.uniprot.org/uniprot/Q9Y2H7) |
| Ensembl ID | ENSG00000148231 |
| OMIM | 610335 |
| GeneCards | TIGAR |
| Human Protein Atlas | TIGAR |
| Hippocampus | High expression in CA1 pyramidal neurons, dentate granule cells — regions critical for memory that are affected early in AD |
| Cerebral cortex | Layer 5 pyramidal neurons show prominent TIGAR expression |
| Substantia nigra | Dopaminergic neurons express TIGAR, where it may modulate vulnerability to PD pathology |
| Associated Diseases | AD, Als, AMI, ARM, cancer |
| Interactions | ATM, ATR, CANCER, DNA, ERK, GAIN |
| KG Connections | 111 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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