concept

ACHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1068Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACHE
Key Genes/Proteins	AB, ABCA1, ACETYL-COA, ACHE, AD, ADAM10
Related Diseases	acetylcholine, Aging, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    ACHE["ACHE"]
    ACHE -->|"activates"| Alzheimer["Alzheimer"]
    ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ACHE -->|"activates"| Als["Als"]
    ACHE -->|"activates"| Inflammation["Inflammation"]
    ACHE -->|"activates"| Ms["Ms"]
    ACHE -->|"activates"| Anxiety["Anxiety"]
    ACHE -->|"target for"| Cardiac["Cardiac"]
    BPMC["BPMC"] -->|"inhibits"| ACHE
    MBP["MBP"] -->|"activates"| ACHE
    GENES["GENES"] -->|"activates"| ACHE
    MANF["MANF"] -->|"activates"| ACHE
    FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
    PI3K["PI3K"] -->|"activates"| ACHE
    AKT["AKT"] -->|"activates"| ACHE
    TNF["TNF"] -.biomarker for.-> ACHE
    CAT["CAT"] -.biomarker for.-> ACHE

Outgoing (891)

Target	Relation	Type	Str
ACHE	encodes	protein	0.00
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-6784494f1741	data_in	dataset	1.00
ds-6784494f1741	provides_data_for	dataset	1.00
denervation	promotes	phenotype	0.85
Als	inhibits	disease	0.85
Acetylcholine	degrades	compound	0.82
Apoptosis	activates	pathway	0.80
Als	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
MICROGLIA	activates	cell_type	0.70
OLIGODENDROCYTE	interacts_with	cell_type	0.70
GRIA1	regulates	gene	0.70
BIN1	markers	gene	0.70
TNF	expresses	gene	0.70
BDNF	biomarker_for	gene	0.70
ASTROCYTE	interacts_with	cell_type	0.70
CDK5	inhibits	gene	0.70
C9ORF72	expresses	gene	0.70
OLIGODENDROCYTES	interacts_with	cell_type	0.70
FUS	associated_with	gene	0.70
RAGE	enhances	gene	0.70
TREM2	targets	gene	0.70
MOTOR NEURON	associated_with	cell_type	0.70
NEURONS	associated_with	cell_type	0.70
PARP1	inhibits	gene	0.70
APOE	mediates	gene	0.70
DRD2	inhibits	gene	0.70
STING	interacts_with	gene	0.70
APP	biomarker_for	gene	0.70
APP	causes	gene	0.70
ASTROCYTE	markers	cell_type	0.70
APOE	activates	gene	0.70
APOE	targets	gene	0.70
LRP1	activates	gene	0.70
APOE	interacts_with	gene	0.70
FTD	targets	disease	0.70
BACE1	interacts_with	gene	0.70
FTD	associated_with	disease	0.70
STING	disrupts	gene	0.70
TREM2	interacts_with	gene	0.70
MAO	targets	gene	0.70
STAT3	targets	gene	0.70
NEURONS	regulates	cell_type	0.70
BACE1	targets	gene	0.70
NOTCH	activates	gene	0.70
PSEN1	targets	gene	0.70
MACROPHAGE	transports	cell_type	0.70
HTT	expresses	gene	0.70

Incoming (177)

Source	Relation	Type	Str
H6	donepezil_target	hypothesis	0.00
ACHE	encodes	gene	0.00
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ds-6784494f1741	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
Bpmc	inhibits	compound	0.90
Bpmc	downregulates	compound	0.90
Chlorogenic acid	downregulates	compound	0.85
Fisetin	downregulates	compound	0.85
NORAD	regulates	gene	0.80
APOPTOSIS	activates	gene	0.80
BPMC	inhibits	drug	0.72
NEUROTOXICITY	activates	gene	0.70
GFAP	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
APP	causes	gene	0.65
NEURODEGENERATION	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
MAOA	therapeutic_target	gene	0.60
SMPD1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CLU	associated_with	gene	0.60
BACE1	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
BDNF	regulates	gene	0.60
SIRT1	regulates	gene	0.60
TRKB	regulates	gene	0.60
HRAS	therapeutic_target	gene	0.60
CIRCADIAN RHYTHM	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
CFB	associated_with	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
ARG1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
GAD2	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
MAPK8	therapeutic_target	gene	0.60
PRESENILIN	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AMPK	protects_against	gene	0.60
INS	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
GDNF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning ACHE in their description or question text

No additional research found