gene

CFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

0Experiments

0Debates

Summary

CFB — Complement Factor B

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CFB
Full Name	Complement Factor B
Protein Type	Protease
Function	Complement Factor B (CFB) is a serine protease that plays a critical role in the alternative pathway of the complement system.
Pathways	Alternative Complement Pathway, Glycolysis, Complement, Immune Response, Myelination
GeneCards	CFB
Human Protein Atlas	CFB
Multiple Sclerosis	CFB expression is elevated in demyelinating lesions [9]
Brain	CFB is expressed at low levels in healthy brain tissue, primarily by astrocytes and microglia
Regional Distribution	Higher expression in the hippocampus and cerebral cortex
Upregulation	Strongly induced during neuroinflammation and in neurodegenerative disease states
Cellular Localization	Secreted protein, localizes to blood-brain barrier and choroid plexus in brain
Associated Diseases	Als, Alzheimer
Interactions	AND, CCL2, COMPLEMENT, Cytokine, CYTOKINES, GLAUCOMA
KG Connections	95 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CFB — Complement Factor B

gene · 623 words

→

CFB Protein — Complement Factor B

protein · 638 words

→

Pathway Diagram

graph TD
    CFB["CFB"]
    Alternative_Complement_Pathway["Alternative Complement Pathway"]
    Hypertension["Hypertension"]
    Autoimmune["Autoimmune"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    Inflammation["Inflammation"]
    Glaucoma["Glaucoma"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    IL_6["IL-6"]
    Glycolysis["Glycolysis"]
    Complement["Complement"]
    Immune_Response["Immune Response"]
    GLAUCOMA["GLAUCOMA"]
    NEURODEGENERATION["NEURODEGENERATION"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    COMPLEMENT["COMPLEMENT"]
    AND["AND"]
    CYTOKINES["CYTOKINES"]
    CFB -->|"component_of"| Alternative_Complement_Pathway
    CFB -->|"activates"| Hypertension
    CFB -->|"activates"| Autoimmune
    CFB -->|"activates"| Neurodegeneration
    CFB -->|"activates"| Neuroinflammation
    CFB -->|"activates"| Inflammation
    CFB -->|"activates"| Glaucoma
    CFB -.->|"inhibits"| Neuroinflammation
    CFB -.-|"associated"| Alzheimer
    CFB -.-|"associated"| Als
    CFB -->|"activates"| IL_6
    CFB -->|"activates"| Glycolysis
    CFB -->|"activates"| Complement
    CFB -->|"activates"| Immune_Response
    CFB -->|"activates"| GLAUCOMA
    CFB -->|"activates"| NEURODEGENERATION
    CFB -->|"activates"| NEUROINFLAMMATION
    CFB -->|"activates"| COMPLEMENT
    CFB -->|"activates"| AND
    CFB -.->|"inhibits"| CYTOKINES
    style CFB fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (68)

Target	Relation	Type	Str
Alternative Complement Pathway	component_of	pathway	0.95
Hypertension	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Autoimmune	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Glaucoma	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neuron	inhibits	cell_type	0.60
Astrocyte	expressed_in	cell_type	0.60
Complement System	activates	pathway	0.60
Cytokine	inhibits	protein	0.60
Il-1	expressed_in	protein	0.60
Vegf	associated_with	protein	0.60
CLU	causes	gene	0.60
CTSF	causes	gene	0.60
SMPD1	causes	gene	0.60
CYTOKINES	inhibits	gene	0.60
ACHE	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
SMOC2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
Myelination	associated_with	pathway	0.60
SMPD1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CLU	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
CTSF	associated_with	gene	0.60
VEGFB	associated_with	gene	0.60
JNK	biomarker_for	gene	0.60
STAT1	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
CR1	expressed_in	gene	0.60
Glycolysis	activates	pathway	0.60
Complement	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Immune Response	associated_with	pathway	0.60
Endothelial	associated_with	cell_type	0.60
STAT1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
JNK	expressed_in	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60

Incoming (27)

Source	Relation	Type	Str
ASTROCYTE	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
SMOC2	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
STAT1	expressed_in	gene	0.60
C5	expressed_in	gene	0.60
ACHE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYTOKINES	inhibits	gene	0.60
CCL2	inhibits	gene	0.60
C3	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CTSF	associated_with	gene	0.60
VEGFB	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
APOE	causes	gene	0.60
BIN1	causes	gene	0.60
C5	causes	gene	0.60
C1R	expressed_in	gene	0.55
C1S	expressed_in	gene	0.55
C3	expressed_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CFB in their description or question text

No additional research found