protein

MAOA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAOA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

MAOA is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Cancer. Connected to 19 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MAOA
Full Name	Monoamine Oxidase A
Chromosome	Xp11.23
Protein Family	Monoamine oxidase family
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	59.7 kDa
Pathways	Neurotoxicity
UniProt ID	[P21397](https://www.uniprot.org/uniprot/P21397)
NCBI Gene ID	4128
Ensembl ID	ENSG00000189221
OMIM	309850
GeneCards	MAOA
Human Protein Atlas	MAOA
Neurotransmitters	Serotonin (5-HT), norepinephrine, dopamine
Associated Diseases	cancer, Inflammation, Neurodegeneration, Neuroinflammation
Interactions	ADRA2A, AGING, AKT, AND, APP, BCL2
KG Connections	115 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAOA Gene

gene · 699 words

→

MAOA Protein

protein · 840 words

→

Pathway Diagram

graph TD
    MAOA["MAOA"]
    Aging{"Aging"}
    MAOA -->|"activates"| Aging
    Ms{"Ms"}
    MAOA -->|"activates"| Ms
    Cancer{"Cancer"}
    MAOA -->|"activates"| Cancer
    Tumor{"Tumor"}
    MAOA -->|"activates"| Tumor
    CANCER["CANCER"]
    MAOA -->|"activates"| CANCER
    neurodegeneration["neurodegeneration"]
    MAOA -->|"implicated in"| neurodegeneration
    IL6["IL6"]
    IL6 -->|"activates"| MAOA
    RANKL["RANKL"]
    RANKL -->|"activates"| MAOA
    SHH["SHH"]
    SHH -->|"activates"| MAOA
    style MAOA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (82)

Target	Relation	Type	Str
Inflammation	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Obesity	inhibits	disease	0.65
Als	inhibits	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Apoptosis	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Akt	therapeutic_target	protein	0.60
SLC6A4	targets	gene	0.60
GABRA2	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
RPN2	activates	gene	0.60
cancer	activates	disease	0.60
RPN2	causes	gene	0.60
cancer	causes	disease	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
PTGS2	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
MAOB	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
ARG1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
GAD2	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
MAPK8	therapeutic_target	gene	0.60
GABRA2	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
CANCER	activates	gene	0.60
AND	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60

Incoming (33)

Source	Relation	Type	Str
ADRA2A	activates	gene	0.60
CTSD	activates	gene	0.60
ADRA2A	causes	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
AND	inhibits	gene	0.60
IL6	targets	gene	0.60
GABRA2	targets	gene	0.60
GFAP	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
AKT1	targets	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AKT	activates	gene	0.60
GABRA2	associated_with	gene	0.60
MITOCHONDRIAL DNA	inhibits	gene	0.60
GENES	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
DNA	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
IL6	activates	gene	0.60
RANKL	activates	gene	0.60
SHH	activates	gene	0.60
HMOX1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
SLC6A4	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
gabra2	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAOA in their description or question text

No additional research found